Collaborative Research: RoL: FELS: Workshop - Rules of Life in the Context of Future Mathematical Sciences

ROL：FELS：协作性提案研讨会-未来数学科学背景下的生命规则将由乔治梅森大学、俄亥俄州立大学和密歇根大学联合主办。会议将于2018年10月4日至6日在弗吉尼亚州亚历山大市举行，50名教师专家和30名来自数学和生物等不同领域的研究生和博士后将齐聚一堂。这次会议的主要目标之一是在NSF的十大想法之一的生命规则下帮助完善数学生物学的新兴研究领域。会议将有助于促进数学生物学新思想的交流，特别是了解生命系统的组织原则和规则。这次交流将通过各种活动来完成，包括主旨演讲、集思广益亲和力测绘活动、教师闪电讲座、学生海报演示以及来自各机构和领先的数学生物研究所的专家小组演示。将汇总和改进讨论结果，最终出版一份白皮书。这份白皮书将在网上免费提供，会议组织者(Pis Dawes、Eisenberg和Seshaiyer)将在其他讲习班和专题讨论会上进一步传播白皮书中的想法。会议还将为研究生以及博士后研究员和新的博士学位持有者提供机会，在类似于专业学科会议的环境中介绍他们的研究。具体的会议活动将集中于(不限于)：(A)对生物过程结果的新的和预测性的理解；(B)了解多细胞结构出现的基本规则；(C)了解昼夜节律和季节节律的调节；(D)在任何规模上重新设计可持续和有弹性的生物系统；以及(E)了解社会互动和经验在通过遗传和表观遗传变化重塑基因组方面的作用。预计这次会议将有助于构建具有预测能力的全面的基因组/环境到表型组理论，这些理论可以帮助设计表型以应对环境挑战或导致下一代最先进的技术。会议形式和广泛的社区参与将发展数学生物学领域的优先领域，涉及NSF的一个重要想法，即理解生命规则，这将(A)使发现能够更好地理解复杂的生物相互作用，并确定跨尺度的因果、预测性关系，以及(B)有助于确定基因组和表型多样性之间的联系，以涵盖跨越多个空间和时间尺度的生物和环境过程。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

The RoL: FELS: Collaborative Proposal Workshop - Rules of Life in the Context of Future Mathematical Sciences will be hosted jointly by George Mason University, Ohio State University, and University of Michigan. The conference will be held in Alexandria, Virginia on October 4-6, 2018 and will bring together 50 faculty experts and 30 graduate and post-doctoral students from a variety of fields spanning mathematics and biology. One of the main goals of the conference is to help refine emerging research areas in mathematical biology under the Rules of Life, one of the NSF's ten Big Ideas. The conference will help to promote the exchange of new ideas in mathematical biology, specifically to understand the organizational principles and rules of living systems. This exchange will be accomplished through a variety of activities including keynote presentations, brainstorming affinity mapping activities, faculty lightning talks, student poster presentations and expert panel presentations from agencies and leading mathematical biology institutes. Outcomes of the discussions will be aggregated and refined, ultimately resulting in the publication of a white paper. This white paper will be freely available online, and the conference organizers (PIs Dawes, Eisenberg and Seshaiyer) will further disseminate the ideas in the white paper at other workshops and symposia. The conference will also provide graduate students as well as post-doctoral fellows and new doctoral degree holders with an opportunity to present their research in a setting similar to professional disciplinary conferences.Specific conference activities will focus on topics (not limited to): (a) new and predictive understanding of outcomes of biological processes; (b) understanding the basic rules for the emergence of multicellular structures; (c) understanding regulation of circadian and seasonal rhythms; (d) re-engineering sustainable and resilient biological systems at any scale and; (e) understanding role of social interactions and experiences in reshaping the genome through genetic and epigenetic changes. It is expected that the conference will help to frame comprehensive genome/environment-to-phenome theories with predictive capability that can help design phenotypes to respond to environmental challenges or lead to next generation state-of-the-art technologies. The conference format and broad community participation will develop priority areas in mathematical biology addressing one of the NSF Big Ideas, Understanding the Rules of Life, that will (a) enable discoveries that will allow better understanding of complex biological interactions and identify causal, predictive relationships across scales and (b) help to identify connections between genomic and phenotypic diversity to encompass biological and environmental processes across multiple scales of space and time.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.