TRANSLUMINAL ANGIOPLASTY CONGENITAL HEART DISEASE RES

动物研究的长期目标是开发新技术， 治疗某些形式的先天性心脏病通过使用 经皮腔内血管成形术。 更具体而言是 本工作旨在评价导管球囊扩张治疗主动脉瘤 瓣膜狭窄，造成局部间隔缺损，并扩张狭窄 体肺分流 待评价的实验程序 可以通过提供新的非外科手术， 治疗患有先天性心脏病的婴儿和年轻人的方法 心脏状况 犬将用于研究。 血流动力学 将评价主动脉流出道球囊闭塞的影响 主动脉缩窄诱导的左心室肥大。 的 主动脉瓣环耐受不同程度的 大直径球囊血管成形导管引起的过度扩张 也将进行评估。 固定直径导管球囊扩张术 还将在狗中研究心房壁。 的风险和 固定球囊房间隔缺损扩张术的疗效观察 手术将与当前的拉穿式和/或刀片式中隔造口术进行比较 程序. 最后，狗与手术本地和Gortex 将研究体肺分流，以评估形态学 血管成形术扩张和分流管过度扩张的结果。 临床经验表明，狭窄的肺-体分流确实 对血管成形术的反应不如类似的狭窄 髂股部有分流 研究结果应 提供与潜在临床应用相关的重要数据 非手术、经皮经导管球囊扩张术， 治疗先天性心脏病 这些研究也应该扩大我们的 关于局限性和潜在风险的当前知识：获益 这些程序的比例。

The long term goal of the animal research is to develop new techniques for treating some forms of congenital heart disease through the use of percutaneous transluminal angioplasty procedures. More specifically, the work is designed to evaluate catheter balloon dilatation to treat aortic valve stenosis, create localized septal defects, and dilate stenotic systemic-pulmonary shunts. The experimental procedures to be evaluated may have direct clinical application by providing new non-surgical approaches to treating infants and young adults suffering from congenital heart conditions. Dogs will be used for the studies. The hemodynamic effects of balloon occlusion of the aortic outflow tract will be evaluated in animals with aortic banding induced left ventricular hypertrophy. The ability of the aortic annulus to tolerate varying degrees of overdistension produced by large diameter balloon angioplastic catheters will also be evaluated. Fixed diameter catheter balloon dilatation of the interatrial wall will also be studied in dogs. The risks and effectiveness of the fixed balloon atrial septal defect dilatation procedure will be compared to current pull-through and/or blade septostomy procedures. Finally, dogs with surgically native and Gortex systemic-pulmonary shunts will be studied to evaluate morphological results of angioplasty dilatation and overdilatation of the shunts. Clinical experience indicates that stenotic pulmonary-systemic shunts do not respond to angioplasty procedures as successfully as similar stenotic shunts in the iliac and femoral region. Results of the studies should provide important data relating to the potential clinical application of non-surgical, percutaneous transcatheter balloon dilatation procedures for treating congenital heart disease. The studies should also extend our current knowledge regarding the limitations and potential risk:benefit ratio of such procedures.