EFFECTS OF NUTRIENTS IN HYPERTENSION

此补充应用程序请求支持完成 日粮钙和钙交互作用的营养学研究 高血压病患者的钠水平。潜在的假设 这项研究的结论是，膳食补钙可以降低血液 高血压患者的血压。虽然有流行病学数据 这表明钙的摄入量会影响血压， 这些数据及其解释是有争议的。此外， 钙的作用程度(如果存在)及其机制(S)如下 不确定。有人认为，可用资源的可变性 数据可能是由于饮食控制在不同子组中的不同影响 在高血压人群中。因为很明显，更多的信息 在考虑一般饮食建议之前是需要的， 邀请了解决这些问题的提案，目前的研究 有资金支持。 这些正在进行的调查是基于对 与盐敏感性和肾素有关的轻中度高血压病 状态。方法包括测定收缩压和舒张压。 压力、仰卧和直立(随机零技术)，研究 电解质和液体平衡，评估前臂血管的反应性 肾上腺素能激动剂、血小板功能和细胞内研究 电解液。循环中的钙和钠水平，肾素，醛固酮， 儿茶酚胺、甲状旁腺激素和1，25(OH)2-维生素D3水平和 对钙的排泄进行评估。患者被随机分配到精确的- 控制恒定饮食，提供400至2000毫克钙和 每天10到300mEq钠，连续8周，利用3x3因数 重复测量的设计。膳食中钾、氯化物的含量 和镁也是受控制的。重复测定基线 在四周和八周执行测量，以确定范围 以及这些影响的时间进程，并提供对其 潜在的机制。

This supplemental application requests support for the completion of a nutritional study of the effects and interactions of dietary calcium and sodium in patients with essential hypertension. The underlying hypothesis of this study is that dietary calcium supplementation can lower blood pressure in essential hypertension. While there is epidemiologic data suggesting that the level of calcium intake can influence blood pressure, this data and its interpretation are controversial. In addition, the extent of the effect of calcium (if present) and its mechanism(s) are uncertain. It has been suggested that the variability in the available data may be due to differential effects of dietary manipulation in subsets of the hypertensive population. Because it was clear that more information was needed before general dietary recommendations were considered, proposals addressing these issues were invited and the current study funded. These ongoing investigations are based on the careful characterization of mild-to-moderate essential hypertensives as to salt-sensitivity and renin status. Methods include determination of systolic and diastolic blood pressure, supine and upright (random-zero technique), studies of electrolyte and fluid balance, assessment of forearm vascular reactivity to adrenergic agonists, studies of platelet function and intracellular electrolytes. Circulating calcium and sodium levels, renin, aldosterone, catecholamines, parathyroid hormone and 1,25(OH)2-vitamin D3 levels and calcium excretion are assessed. Patients are randomized to precisely- controlled constant diets, providing from 400 to 2000 mg calcium and from 10 to 300 mEq sodium/day for eight weeks, utilizing a 3 x 3 factorial design with repeated measures. The dietary content of potassium, chloride and magnesium are also controlled. Repeated determination of baseline measures are performed at four and eight weeks to define both the extent and time course of these effects and to provide insight into their potential mechanisms.