权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

IHD INCIDENCE AND INDICES OF BODY-FAT DISTRIBUTION

IHD 发病率和身体脂肪分布指数

基本信息

批准号：
2219741
负责人：
HENRY S KAHN
金额：
$ 33.74万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1990
资助国家：
美国
起止时间：
1990-05-01 至 1995-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2219741
关键词：
body height body physical characteristic cardiovascular disorder epidemiology case history disease /disorder proneness /risk female hospital patient care human subject interview lifestyle male myocardial ischemia /hypoxia obesity postmortem statistics /biometry

项目摘要

Reports from Sweden, Hawaii and France have each demonstrated that abdominal obesity, i.e., central, upper-body, or "apple", can be predictive of ischemic heart disease (IHD). These prospective cohort studies employed different simple indicates of body-fat distribution such as waist-to-hip circumference ratio or subscapular skinfold. Their similar results, however, suggest that increased abdominal obesity confers approximately a two-fold increased risk of IHD among middle-aged men. The effect among females may be stronger. This proposal approaches the epidemiologic relationship between IHD incidence and simple indices of fat distribution using the case-control method instead of a more costly prospective cohort. Two parallel, case- control protocols are proposed. A hospital based investigation will study 450 early survivors of a first IHD event (cases), 450 matched neighborhood controls and 450 hospital controls (suspected of IHD, but with negative work-up). A morgue-based study will involve 354 non-survivors of a first IHD event, 354 matched neighborhood controls and 354 controls who died from an acute process and were free of IHD. These two studies will permit the testing of alternative fat-distribution indices which may be stronger risk factors for IHD incidence than the waist-to-hip ratio of the subscapular skinfold. The proposed anthropometric data sets will include 6 girths, 7 skinfolds, abdominal sagittal diameter, height and weight. Principal component and canonical correlations analyses will assist the researchers to identify combinations of these measures which efficiently distinguish cases from controls. The analyses for both protocols will consider males and females separately. Possible confounders of the association between fat-distribution indices and IHD (e.g., race, age, tobacco use, alcohol use, diabetes) will be considered and, if required, adjusted for in multivariate analysis. These protocols will provide a previously unavailable combination, in one America data set, of well documented IHD outcomes and a variety of fat- distribution measurements. Any improved indices identified in these studies will have potential utility for future prospective investigations, for intergroup comparisons of IHD risk, for patient assessment and perhaps for the rapid evaluation of protective interventions (e.g., diet, exercise programs) against cardiovascular disease.

来自瑞典、夏威夷和法国的报告都表明，腹型肥胖，即中央、上半身或“苹果”，可以预测。缺血性心脏病(IHD)。这些前瞻性队列研究采用了身体脂肪分布的不同简单指标，如腰围到臀围周长比或肩胛骨下皮褶。他们相似的结果，然而，这表明腹部肥胖症的增加大约会导致中年男性患IHD的风险增加了两倍。它们之间的影响雌性可能更强壮。这项建议探讨了IHD之间的流行病学关系应用病例对照研究脂肪分布的发生率和简单指标方法，而不是更昂贵的预期队列。两个平行的案例- 提出了相应的控制协议。一项基于医院的调查将研究 450名首次IHD事件的早期幸存者(病例)，450名匹配的邻居对照和450个医院对照(疑似IHD，但阴性锻炼)。一项以停尸房为基础的研究将涉及354名第一次死亡的人 IHD事件，354名匹配的邻居对照和354名对照死于这是一个急性的过程，没有发生IHD。这两项研究将允许对替代脂肪分布进行测试。可能是IHD发病率的更强危险因素的指标肩胛骨下皮褶的腰臀比。拟议的人体测量学数据集将包括6个周长，7个皮褶，腹部矢径，身高和体重。主成分和典型相关性分析将有助于研究人员找出这些措施的组合，从而有效地区分病例和对照。对这两个协议的分析将把男性和女性分开来考虑。可能的混杂因素脂肪分布指数与IHD(如种族、年龄、烟草使用、酒精使用、糖尿病)将被考虑，如果需要，在多变量分析中进行了调整。这些协议将提供以前不可用的组合，在一个美国的数据集，记录了IHD的结果和各种脂肪- 分布测量。在这些文件中确定的任何改进的指数这些研究将对未来的前瞻性研究具有潜在的实用价值，用于IHD风险的组间比较，用于患者评估，也许用于快速评估保护性干预措施(例如，饮食、锻炼计划)预防心血管疾病。