BARORECPTOR MORPHOLOGY DURING HYPERTENSION

这个项目的具体目标是检验这样一个假设 高血压期间压力感受器重置的部分原因是 颈动脉神经支配和/或血供的形态变化 鼻窦压力感受器区域本身。将实现这些具体目标 通过实验确定：(1)高血压是否会沉淀 鼻窦血液供应的改变；(2)是否有形态上的改变 窦壁的改变，这将解释减少 该血管带的扩张性；(3)高血压是否开始或 受压力感受器和交感神经增加或减少的影响 纤维对鼻窦的支配；以及(4)如果鼻窦的形态发生改变 压力感受器神经末梢和它们所连接的组织 高血压之前的或高血压引起的。血管铸型/扫描 电子显微镜、亚甲蓝生命染色、选择性神经 退化和定量透射电子显微镜技术 将被用来回答关于这一形态的重要问题 进展性高血压时的关键压力感受区。这个 自发性高血压大鼠(SHR)及其正常血压 (WKY)染色将作为人类原发性高血压的模型 这些研究。人们对基本的压力感受器知之甚少 交感神经支配和颈动脉窦的血液供应。这些研究 本申请中概述的内容将提供急需的信息， 客观地获得有关压力感受器的形态相关性 早期和进展性高血压的发病机制 其中有哪些尚不清楚。

The specific aims of this project are to test the hypothesis that baroreceptor resetting during essential hypertension is due, in part, to a morphological change in the innervation and/or blood supply to the carotid sinus baroreceptor region itself. These specific aims will be approached experimentally by determining: (1) whether hypertension precipitates changes in the blood supply to the sinus; (2) if there are morphological alterations to the sinus wall which would account for decreased distensibility of this vascular zone; (3) whether hypertension initiates or is affected by an increase or decrease in baroreceptor and sympathetic fiber innervation to the sinus; and (4) if alterations in the morphology of baroreceptor nerve terminals and the tissue they are coupled with occur before, or as a result of, hypertension. Vascular casting/scanning electron microscopy, methylene blue vital staining, selective nerve degeneration, and quantitative transmission electron microscopy techniques will be used to answer important questions about the morphology of this crucial baroreceptive zone during progressive hypertension. The spontaneously hypertensive rat (SHR) and its normotensive Wistar-Kyoto (WKY) stain will be used as a model of human essential hypertension in these studies. Little is known about the basic baroreceptor and sympathetic innervation and blood supply to the carotid sinus. The studies outlined in this application will provide much needed information, objectively obtained, about the morphological correlates of baroreceptor involvement in early and progressive essential hypertension, the etiology of which remains unknown.