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BARORECPTOR MORPHOLOGY DURING HYPERTENSION

高血压期间的压力感受器形态

基本信息

批准号：
3350566
负责人：
JOHN T HANSEN
金额：
$ 4.83万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-07-01 至 1988-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3350566
关键词：
baroreceptors carotid sinus hypertension innervation scanning electron microscopy sympathetic nervous system

项目摘要

The specific aims of this project are to test the hypothesis that baroreceptor resetting during essential hypertension is due, in part, to a morphological change in the innervation and/or blood supply to the carotid sinus baroreceptor region itself. These specific aims will be approached experimentally by determining: (1) whether hypertension precipitates changes in the blood supply to the sinus; (2) if there are morphological alterations to the sinus wall which would account for decreased distensibility of this vascular zone; (3) whether hypertension initiates or is affected by an increase or decrease in baroreceptor and sympathetic fiber innervation to the sinus; and (4) if alterations in the morphology of baroreceptor nerve terminals and the tissue they are coupled with occur before, or as a result of, hypertension. Vascular casting/scanning electron microscopy, methylene blue vital staining, selective nerve degeneration, and quantitative transmission electron microscopy techniques will be used to answer important questions about the morphology of this crucial baroreceptive zone during progressive hypertension. The spontaneously hypertensive rat (SHR) and its normotensive Wistar-Kyoto (WKY) stain will be used as a model of human essential hypertension in these studies. Little is known about the basic baroreceptor and sympathetic innervation and blood supply to the carotid sinus. The studies outlined in this application will provide much needed information, objectively obtained, about the morphological correlates of baroreceptor involvement in early and progressive essential hypertension, the etiology of which remains unknown.

该项目的具体目标是检验以下假设：原发性高血压期间压力感受器重置部分是由于颈动脉神经支配和/或血液供应的形态变化窦压力感受器区域本身。将实现这些具体目标通过实验确定：（1）是否会诱发高血压鼻窦血液供应的变化； (2)是否存在形态窦壁的改变会导致减少该血管区的扩张性； (3) 是否有高血压发生或受压力感受器和交感神经增加或减少的影响窦的纤维神经支配； (4) 如果形态发生改变压力感受器神经末梢及其所连接的组织发生高血压之前或之后。血管铸型/扫描电子显微镜、亚甲蓝活体染色、选择性神经变性和定量透射电子显微镜技术将用于回答有关该形态的重要问题进行性高血压期间的关键压力感受区。这自发性高血压大鼠（SHR）及其正常血压 Wistar-Kyoto (WKY)染色将被用作人类原发性高血压模型这些研究。对于基本的压力感受器和交感神经支配和颈动脉窦的血液供应。研究本申请中概述的内容将提供急需的信息，客观地获得关于压力感受器的形态相关性参与早期和进行性原发性高血压，其病因学其中仍然未知。