THE SULFA DRUGS: SCIENCE, MEDICINE, AND INDUSTRY

磺胺药物：科学、医学和工业

• 批准号: 3373582
• 负责人: JOHN E LESCH
• 金额: $ 3.69万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-08-01 至 1986-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3373582
• 关键词: alkaloids; books; chemotherapy; drug /agent; drug metabolism; history of life science; industry; pharmacology; sulfanilamides

This proposal is for support for the research and writing of parts of a book on the history of the sulfa drugs. The whole study includes the background to chemotherapy in 19th-century pharmacology; pharmacological research at Bayer/I.G. Farbenindustrie 1900-1936; Gerhard Domagk and the discovery of the prontosil; sulfnonamides research at the Institut Pasteur, Paris; early laboratory and clinical studies in Britain and the U.S.; the development of sulfanilamide derivatives; the Elixer Sulfanilamide disaster and drug-control legislation; the sulfonamides in World War II, mechanism of action studies 1936-1950; and the situation of chemotherapy research in this century. The relations of science and technology, the industrialization of science, the international character of the scientific enterprise, the focusing of public attention on the sciences, the increasing involvement of government, and the nature of disciplinary boundaries are major themes of 20th-century science potentially represented in this investigation. Research includes study of published primary and secondary literature, and of archival materials gathered in Europe and the U.S. Work for the grant period will emphasize the writing of chapter drafts on the subtopics listed above for which research has been completed; and the extension of research to cover the remaining sub-topics.

本提案旨在支持研究和撰写部分 关于磺胺类药物历史的书 整个研究包括 19世纪药理学中的化疗背景;药理学 拜耳/I.G.的研究Farbenindustrie 1900-1936; Gerhard Domagk and the 在巴斯德研究所发现了磺胺类药物， 巴黎;在英国和美国的早期实验室和临床研究;的 磺胺衍生物的开发; Elixer磺胺灾难 和药物管制立法;磺胺在第二次世界大战中，机制 1936-1950年的行动研究; 这个世纪。 科学与技术的关系 科学产业化，科学产业的国际性， 企业，公众对科学的关注， 政府越来越多的参与，纪律的性质， 边界是20世纪科学的主要主题， 参与调查 研究包括对已发表的主要和 二手文献，以及在欧洲和欧洲收集的档案材料， 美国 工作的补助金期间将强调第章的写作 已完成研究的上述分专题草案; 并扩大研究范围，以涵盖其余的分专题。