TRICYCLIC ANTIDEPRESSANTS AND COGNITIVE TOXICITY

系统性急性和慢性三环类抗抑郁药（TCA）的作用 治疗和停药的影响进行评估， 生理心理和认知功能 抑郁症患者 被随机分配到治疗三个月， 抗胆碱能TCA，反复评价，然后随机分配至 继续或停止治疗6个月。 特别是广泛的生殖学和生理学评估， 此外，在基线和3个月间隔时进行认知功能检查 每周一次和每两周一次的中期访视，以比较TCA的效果， 评价纵向治疗过程。 主要分析将： (1)与年龄、抑郁症程度和类型、抗胆碱能药物相关 活动，和特定的TCA认知功能;（2）评估生理， 心理和认知功能作为描述质量的 缓解和复发的预测因素。

Effects of systematic acute and chronic tricyclic antidepressant (TCA) treatment and treatment withdrawal are assessed in terms of effects on physiologic, psychologic, and cognitive function. Depressed outpatients are assigned randomly to treatment for three months on a high or low anticholinergic TCA, evaluated repeatedly, and then randomized to continuation or discontinuation treatment for six additional months. Particularly extensive assessments of symptomatology and physiologic and cognitive function are made at baseline and 3-month intervals in addition to weekly and biweekly interim visits in order to compare TCA effects and to evaluate longitudinal course of treatment. Principal analyses will: (1) relate age, degree and type of depression, drug anticholinergic activity, and specific TCA to cognitive function; (2) assess physiological, psychological, and cognitive function as descriptors of quality of remission and predictors of relapse.