HIV ASSOCIATED HEART DISEASE

艾滋病毒相关心脏病

• 批准号: 3359260
• 负责人: JUDITH A HSIA
• 金额: $ 44.11万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3359260
• 关键词: AIDS; AIDS therapy; antiAIDS agent; antiantibody; antiviral agents; arrhythmia; biopsy; cardiotoxin; cellular immunity; echocardiography; electrocardiography; heart disorder diagnosis; histopathology; human immunodeficiency virus 1; human subject; immunopathology; immunosuppressive; inflammation; longitudinal human study; myocarditis; myocardium disorder; natural gene amplification; noninvasive diagnosis; nucleic acid hybridization; nucleic acid probes; opportunistic infections; pathology; patient /disease registry; zidovudine

Several lines of evidence have confirmed the association between the syndromes associated with HIV infection and heart disease in humans. Clinically significant congestive cardiomyopathy and echocardiographic abnormalities are commonly found. The first project described in this proposal will develop natural history data regarding the incidence, clinical course, prognostic significance, role of non-invasive evaluation and effects of treatment with anti-viral and immunosuppressive agents on HIV-associated heart disease. This proposal will establish an interdisciplinary cooperative research effort enrolling patients from three District of Columbia academic institutions with diverse patient populations. The research group will contain all the necessary components to study the natural history of HIV-associated heart disease and provide important data regarding the effects of pharmacologic intervention on the development and course of heart disease. Cardiac histopathologic abnormalities in patients with HIV infection have been demonstrated in both post-mortem specimens and endomyocardial biopsy samples. It is not known whether the observed abnormalities are due to 1) direct infection of cardiocytes with HIV, 2) damage from a different infectious agent, or 3) immune-mediated damage of heart cells stimulated by the presence of HIV or other infection. Project 2 of this proposal will evaluate a number of possible mechanisms underlying the development of HIV heart disease.

几条证据证实了两者之间的联系 年与艾滋病毒感染和心脏病相关的综合征 人类。临床上显著的充血性心肌病和 超声心动图异常是常见的。第一 本建议书中描述的项目将开发自然历史数据 关于发病率、临床病程、预后意义， 无创性评估的作用和治疗的效果 抗病毒和免疫抑制剂治疗HIV相关心脏 疾病。这项提议将建立一个跨学科的 合作研究努力招募来自三个地区的患者 拥有不同患者的哥伦比亚大学学术机构 人口。研究小组将包含所有必要的 研究HIV相关心脏自然病史的成分 疾病，并提供了关于 药物干预对血液病发生发展过程的影响 心脏病。 HIV感染者的心脏组织病理学异常 在这两个尸检样本中都发现了感染 和心内膜心肌活检样本。目前还不清楚是否 观察到的异常是由于1)直接感染 HIV感染的心肌细胞，2)不同感染方式对心肌细胞的损伤 或3)受刺激的心肌细胞的免疫介导的损伤 由于艾滋病毒或其他感染的存在。这是第二个项目 提案将评估一些可能的机制 是艾滋病毒心脏病发展的根本原因。