CHRONOBIOLOGIC CARDIOVASCULAR TRACKING FROM BIRTH

从出生开始的时间生物学心血管追踪

• 批准号: 3357912
• 负责人: FRANZ HALBERG
• 金额: $ 35.12万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3357912
• 关键词: aldosterone; angiotensin /renin /aldosterone hypertension; blood chemistry; blood pressure; cardiovascular disorder diagnosis; cardiovascular disorder epidemiology; case history; circadian rhythms; dehydroepiandrosterone; disease /disorder proneness /risk; echocardiography; familial hypertension; family; heart rate; human subject; information systems; longitudinal human study; newborn human (0-6 weeks); noninvasive diagnosis; parents; preschool child (1-5); questionnaires; saliva; thyrotropin

To assess circadian rhythm development & congenital cardiovascular disease risk, blood pressure (BP), heart rate (HR) & salivary aldosterone will be monitored for 48 hours after birth on 330 newborns. At 48 hours after birth, circulating aldosterone, TSH &DHEA-S & an echocardiogram will be determined. Parents & other accessible family members will contribute a 48-hours BP & HR profile with a fully ambulatory BP monitor or using specially-designed minimal sampling schemes that do not interfere with daily activities yet allow assessment of BP & HR dynamics, with a room-restricted monitor. A questionnaire will inquire notably about a family history of high BP & diabetes. All infants will be individually tracked, at equivalent or similar to 1.5-year intervals to provide up to 4 profiles (210 infants) between equivalent or similar to 0.5 and equivalent or similar to 4.5 years of age, for a 48-h BP, HR & salivary aldosterone profile, a blood aldosterone, TSH & DHEA-S & an echocardiogram. Chronobiologic analyses will 1) provide reference standards for trend-adjusted means & dynamic cardiovascular features including a chronobiologic index to recognize, at birth, the risk of developing a high BP later in life; 2) quantify age trends; 3) show relations among different (physiologic or imaging) cardiovascular & endocrine variables; 4) indicate the cost-effective neonatal predictor at birth of the follow-up BP & HR means & dynamic characteristics; & 5) compare, by the criterion of BP tracking, the relative merits of an anamnestic or quantitative (familial measurement-based) family history, the chronobiologic & conventional endpoints from familial BP & HP monitoring & the neonatal chronobiologic predictors of cardiovascular disease risk. Cluster analysis should answer the question whether a dynamic neonatal index classifies risk better than the best quantitative family history or BP profile. If so, a neonatal index would gauge the effect of intervention on the pregnant woman & underlie indications for individualized dietary intervention on the newborn.

评估昼夜节律发育和先天性 心血管疾病风险、血压(BP)、心率(HR)和 出生后48小时将监测唾液中的醛固酮 330名新生儿。出生后48小时，循环中的醛固酮， 促甲状腺激素和脱氢表雄酮-S&超声心动图将被测定。家长 &其他可联系的家庭成员将贡献48小时BP 使用完全可移动的BP监护仪或使用 特别设计的最小抽样方案 干扰日常活动，但允许评估BP和HR Dynamic，配有受限于房间的监视器。一份调查问卷将 特别要询问有高血压和糖尿病的家族史。全 婴儿将被单独跟踪，相当于或类似于 每隔1.5年提供最多4份档案(210名婴儿) 相当于或类似于0.5年，相当于或类似于4.5年 年龄，48小时血压，心率和唾液醛固酮水平，血液 醛固酮、促甲状腺激素和脱氢表雄酮-S&超声心动图。 时间生物学分析将为以下方面提供参考标准 趋势调整均值和动态心血管特征包括 一种时间生物学指标，用于在出生时识别 在晚年形成高血压；2)量化年龄趋势；3)显示 不同(生理或影像)心血管疾病之间的关系 和内分泌变量；4)指示具有成本效益的新生儿 出生时的预测因子BP和HR的跟踪均值&动态 特征；5)以BP跟踪为准则，比较 追忆或定量(家族性)的相对优点 基于测量的)家族史、时间生物学和 来自家庭BP和HP监测的传统终点& 新生儿心血管疾病风险的时间生物学预测因子。 聚类分析应该回答这样一个问题，即动态的 新生儿指数对风险的分类比最佳量化指标更好 家族病史或BP档案。如果是这样的话，新生儿指数将衡量 干预对孕妇的影响及其基础 新生儿个体化饮食干预的适应证。