RISK FACTORS IN BRONCHOPULMONARY DYSPLASIA

一个全面的流行病学研究，建议调查 支气管肺发育不良（BPD）的危险因素， 早产儿发生的肺部疾病。 在 第一年，该研究旨在标准化诊断，并制定一个 急性和慢性严重程度分级评分系统 疾病的各个方面。 随后，将进行多因素调查， 阐明BPD与急性肺疾病之间的关系 严重程度，呼吸相关变量，水平衡，营养， 家庭倾向、环境、妊娠和分娩 参数 研究中的重要特征是一致的 诊断标准、大样本量和前瞻性数据 收藏. 在六个新生儿密集中心出生时体重低于1，501克的所有婴儿 威斯康星州的护理单位将进入研究。 基线数据 所有这些都将提交标准化的医院日志， 婴儿。 对于存活7天的新生儿， 进行。 严重程度评分和诊断将基于 医院记录和常规X光片 最终分析将比较 BPD的婴儿与没有BPD的婴儿相比， 混淆因素，并特别强调交互作用。 此外，一组足月新生儿将作为总体 控制

A comprehensive epidemiologic study is proposed for investigating risk factors in Bronchopulmonary Dysplasia (BPD), a chronic pulmonary disease which occurs in premature neonates. In the first year, the study aims to standardize diagnosis and develop a scoring system for grading the severity of acute and chronic aspects of the disease. Subsequently, a multifactorial investigation will be undertaken to elucidate the relationship between BPD, acute lung disease severity, respiration related variables, water balance, nutrition, familial predisposition, environmental, pregnancy and delivery parameters. Important features in the study are uniform diagnostic criteria, large sample size and prospective data collection. All infants below 1,501 grams at birth in six neonatal intensive care units in Wisconsin will be entered in the study. Baseline data and standardized hospital logs will be submitted for all these infants. For neonates surviving 7 days, maternal interviews will be conducted. Severity scoring and diagnosis will be based on the hospital log and routine x-rays. Final analysis will compare infants with BPD to those without BPD, controlling for confounders and placing special emphasis on interaction effects. Additionally, a group of full term neonates will serve as an overall control.