CENTRAL BLOOD PRESSURE REGULATION IN AGED

老年人的中心血压调节

• 批准号: 3353980
• 负责人: RUBEN D BUNAG
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1991-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3353980
• 关键词: aging; animal old age; artery stenosis; baroreceptors; blood pressure; cardiovascular pharmacology; denervation; disease /disorder model; electrostimulus; heart rate; hypertension; hypothalamus; kidney function; laboratory rat; medulla oblongata; neurogenic hypertension; neurotransmitter biosynthesis; neurotransmitter metabolism; reflex; renin; sympathetic nervous system

We propose to test the hypothesis that the hypertension occurring with age results from dysfunction of brain aminergic mechanisms which normally regulate sympathetic vasomotor tone and blood pressure. Whether blood pressure also rises with age in rats, as it does in man, will first be determined by using a properly validated tail-cuff method to monitor blood pressure in different groups of aging Sprague-Dawley and Fischer 344 rats. To test for central dysfunction, cardiovascular and sympathetic nerve responses elicited by stimulating various hypothalamic and medullary centers electrically will be compared with those from younger rats of the same strain. Baroreflex sensitivity will be assessed by recording chronotropic and sympathetic nerve responses produced reflexly as blood pressure is elevated with phenylephrine or lowered with sodium nitroprusside; these baroreflex responses would then be compared with those obtained from younger normotensive or hypertensive rats. Acute and long-term effects of sinoaortic denervation (SAD) on regional hemodynamics, plasma catecholamines, and renin concentration will be measured. Brain amine synthesis and metabolism will be evaluated following renal denervation or arterial stenosis to determine whether aberrant signals from the kidneys contribute to alter central cardiovascular regulation in aged rats. If a good model for simulating the blood pressure elevation that occurs with age can be developed in rats, the model can be used to obtain information that could improve our understanding of age-related cardiovascular dysfunction and help us find ways to reduce mortality and morbidity caused by hypertension in the elderly.

我们建议检验这一假设，即高血压发生与年龄 结果是脑胺能机制功能障碍， 调节交感神经血管紧张度和血压。 血液是否 压力也会随着年龄的增长而上升，就像在人身上一样， 通过使用经过适当验证的尾套方法监测血液来确定 压力在不同年龄组的Sprague-Dawley和Fischer 344大鼠。 检测中枢功能障碍，心血管和交感神经 刺激下丘脑和延髓的各种神经元引起的反应 中心电将与那些年轻的大鼠进行比较， 同样的菌株 压力反射敏感性将通过记录 血液反射产生的变时性和交感神经反应 苯乙醯胺使血压升高，钠使血压降低 硝普钠;这些压力反射反应将与那些 从年轻的血压正常或高血压大鼠获得。 急性和 去窦弓神经（SAD）对局部血流动力学的长期影响， 测量血浆儿茶酚胺和肾素浓度。 大脑 将在肾移植后评价胺的合成和代谢。 去神经支配或动脉狭窄，以确定是否有异常信号， 肾脏参与改变老年人的中枢心血管调节 大鼠 如果一个好的模型来模拟血压升高， 随着年龄的增长，可以在大鼠中发展，该模型可以用来获得 这些信息可以提高我们对与年龄有关的 帮助我们找到降低死亡率的方法， 老年人高血压的发病率。