NUCLEAR MAGNETIC RESONANCE IN SCHIZOPHRENIA

核磁共振在精神分裂症中的应用

• 批准号: 3376316
• 负责人: MARIAN K. DEMYER
• 金额: $ 13.9万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-15 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3376316
• 关键词: aging; brain imaging /visualization /scanning; chlorpromazine; clinical biomedical equipment; electroconvulsive therapy; human subject; interview; longitudinal human study; mental disorder chemotherapy; mental disorder diagnosis; psychobiology; schizophrenia; statistics /biometry; tranquilizer; young adult human (21-34)

The first main objective is to differentiate brain images of 34 schizophrenic patients (Sch) from those of 34 normal (Nr) age- and sex-matched controls using the safe and sensitive technique of nuclear magnetic resonance. Images will be obtained by a Technicare unit using a combination of spin echo (SE) 30/125O and inversion recovery (IR) 400/1250. A 2 1/2 minute preliminary scan is usedto locate two horizontal slices, namely (1) through the Foramen of Monroe and (2) at the widest part of the lateral ventricles. A third and coronal slice will be located through the hypothalamic level. After 13 1/2 minute scan time for each slice, reconstruction of images is performed according to Technicare's observed T1 (OT1) package which allows four images to be developed: (1) MO ratio; (2) OT1 calculated image; (3) OT1 error; and (4) proton density. For each horizontal image, continuous OT1 and spin density values will be obtained for the following 107 pixel areas bilaterally: inferior slice, frontal gray and white, caudate, thalamus, temporal gray and white, occipital gray; lateral ventricle slice, gray and white of frontal, posterior-frontal/anterior-parietal, parietal and occipital. Areas of interest in coronal slice are the diencephalic structures and the temporal lobe. Analyses of variance and discriminant analyses will be used to differentiate diagnostic groups. The second main objective is to locate NMR image changes after 1, 2, 3, and 4 years of neuroleptic medication. The third objective is to locate NMR image changes at one week and six months from baseline following electroconvulsive therapy. The fourth objective is to compare NMR of Sch patients with affective psychotic patients and presumptive Alzheimer's disease patients using tactics similar to those in the first objective. OT1 and spin density values will be compared with validating variables, e.g. symtpoms, neuropsychological test score, EEG, family history and age. Significance: Previous work with brain CT scans and with other imaging techniques such as Positron Emission Tomography (PET) has shown that with other a variable number of Sch patients have evidence of brain pathology. The etiological role of somatic therapies and pre-illness brain injury events are unclear. This research project should help in two ways: (1) Locating safely and with greater precision the brain areas involved in Sch neuropathological processes and (2) More about the role of neuroleptic medication and ECT in production of that neuropathology.

第一个主要目标是区分34个脑图像 精神分裂症患者（Sch）34正常（Nr）年龄-和 使用安全敏感的核技术， 磁共振。 图像将由Technicare单位使用 自旋回波（SE）30/125 O和反转恢复（IR）的组合 400/1250. 一个2 1/2分钟的初步扫描是用来定位两个水平的 切片，即（1）通过门罗孔和（2）在最宽部分 侧脑室 第三个冠状切片将位于 通过下丘脑水平。 在每个扫描13 1/2分钟后， 切片，根据Technicare的 观察到的T1（OT 1）程序包，允许开发四种图像：（1）MO 比率;（2）OT 1计算图像;（3）OT 1误差;和（4）质子密度。 对于每个水平图像，连续的OT 1和自旋密度值将被 对于下面的107个像素区域双侧获得：下切片， 额叶灰色和白色，尾状核，丘脑，颞叶灰色和白色， 枕叶灰色;侧脑室切片，额叶灰色和白色， 后额叶/前顶叶、顶叶和枕叶。 领域 冠状面上感兴趣的是间脑结构和颞叶 耳垂。 方差分析和判别分析将用于 区分诊断组。 第二个主要目标是定位 核磁共振图像的变化后，1，2，3，和4年的抗精神病药物治疗。 第三个目标是定位一周和六周时的NMR图像变化 电休克治疗后较基线的月数。 第四 目的比较Sch与情感性精神病患者的核磁共振（NMR） 患者和假定的阿尔茨海默病患者使用类似的策略， 第一个目标的人。 OT 1和自旋密度值将是 与验证变量（如症状、神经心理测试）相比 评分、EEG、家族史和年龄。 重要性：以前的工作 脑CT扫描和其他成像技术，如正电子发射 断层扫描（PET）已经表明，与其他可变数量的Sch 病人有脑部病变的证据 躯体疾病的病因作用 治疗和患病前脑损伤事件尚不清楚。 本研究 项目应该在两个方面有所帮助：（1）安全地定位， 精确的大脑区域参与Sch神经病理过程， (2)更多关于精神抑制药物和ECT在生产中的作用 神经病理学