TRICYCLIC ANTIDEPRESSANTS AND COGNITIVE TOXICITY

三环类抗抑郁药和认知毒性

• 批准号: 3375496
• 负责人: RICHARD J KAHN
• 金额: $ 32.82万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375496
• 关键词: aging; antidepressants; cognition; depression; drug adverse effect; drug withdrawal; human subject; human therapy evaluation; mental disorder chemotherapy; psychotropic drugs; remission /regression

Effects of systematic acute and chronic tricyclic antidepressant (TCA) treatment and treatment withdrawal are assessed in terms of effects on physiologic, psychologic, and cognitive function. Depressed outpatients are assigned randomly to treatment for three months on a high or low anticholinergic TCA, evaluated repeatedly, and then randomized to continuation or discontinuation treatment for six additional months. Particularly extensive assessments of symptomatology and physiologic and cognitive function are made at baseline and 3-month intervals in addition to weekly and biweekly interim visits in order to compare TCA effects and to evaluate longitudinal course of treatment. Principal analyses will: (1) relate age, degree and type of depression, drug anticholinergic activity, and specific TCA to cognitive function; (2) assess physiological, psychological, and cognitive function as descriptors of quality of remission and predictors of relapse.

系统性急性和慢性三环类抗抑郁药（TCA）的作用 根据对治疗和治疗停药的影响进行评估 生理、心理和认知功能。 抑郁症门诊患者 随机分配接受为期三个月的高或低治疗 抗胆碱能 TCA，反复评估，然后随机分组 继续或停止治疗六个月。 特别广泛的症状学和生理学评估 此外，还以基线和 3 个月为间隔进行认知功能评估 每周和每两周一次的中期访视，以比较 TCA 的效果和 评估纵向治疗过程。 主要分析将： (1) 关联年龄、抑郁程度和类型、抗胆碱能药物 活动以及认知功能的特定 TCA； (2) 评估生理、 心理和认知功能作为质量的描述符 缓解和复发的预测因素。

项目成果

Tricyclic treatment of generalized anxiety disorder.

三环治疗广泛性焦虑症。

• DOI: 10.1016/0165-0327(87)90019-x
• 发表时间: 1987
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Kahn,RJ;McNair,DM;Frankenthaler,LM
• 通讯作者: Frankenthaler,LM

Imipramine and chlordiazepoxide in depressive and anxiety disorders. II. Efficacy in anxious outpatients.

丙咪嗪和氯氮卓治疗抑郁症和焦虑症。

• DOI: 10.1001/archpsyc.1986.01800010081010
• 发表时间: 1986
• 期刊: Archives of general psychiatry
• 作者: Kahn,RJ;McNair,DM;Lipman,RS;Covi,L;Rickels,K;Downing,R;Fisher,S;Frankenthaler,LM
• 通讯作者: Frankenthaler,LM