QUANTITATION OF MYOCARDIAL PERFUSION BY TC-99M-MIBI

通过 TC-99M-MIBI 定量心肌灌注

• 批准号: 3359457
• 负责人: JAMSHID MADDAHI
• 金额: $ 18.51万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-08-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3359457
• 关键词: clinical biomedical equipment; coronary disorder; diagnosis quality /standard; dogs; heart circulation; heart disorder diagnosis; heart imaging /visualization /scanning; human subject; noninvasive diagnosis; radionuclide diagnosis; single photon emission computed tomography; technetium

T1-201 myocardial perfusion scintigraphy has been widely utilized for non- invasive evaluation of coronary artery disease (CAD). Extensive research and development by our group and others has resulted in the development of objective methods for analysis of images and single photon emission computerized tomography (SPECT). Nevertheless, quantitative Tl-201 SPECT has not yet reached its full potential because of suboptimal physical characteristics of the Tl-201 agent. Recently, Technetium-99m labeled Methoxy Isobutyl Isonitrile (Tc-MIBI) has been developed which obviates most of the unfavorable characteristics of Tl-201. The overall objective of this proposal is to develop, validate and assess clinical applications of a noninvasive method for quantitative assessment of myocardial perfusion using Tc-MIBI SPECT. This overall objective is addressed in two separate sections. I. Relative Quantitation of Myocardial Perfusion: The long term objective of this section is to develop, optimize and validate methods for acquisition, filtering, reconstruction, quantitative analysis, and displaying Tc-MIBI SPECT data. The hypothesis to be tested is whether relative quantitation (determination of the volume of abnormally perfused myocardium) of Tc-MIBI Spect data can be implemented in patient studies in a manner in which they will more accurately predict quantitative coronary angiographic findings and the presence and size of perfusion defects. II. Absolute Quantitation of Myocardial Perfusion: The long-term objective of this section is to develop methods to obtain, in the clinical setting, a linear relation between pixel count values and myocardial tracer concentrations and thus obtain truly quantitative imaging. This should result in improved uniformity of normal tissue count distribution, increased lesion contrast and measurement of actual myocardial blood flow. On order to fulfill this objective it is necessary to apply corrections for: Compton Scatter, attenuation and object size of the myocardium due to finite resolution effects.

T1-201心肌灌注核素显像已广泛应用于非 冠状动脉疾病(CAD)的侵入性评估。广泛的研究 以及我们集团和其他人的发展导致了 图像分析和单光子发射的客观方法 计算机断层扫描(SPECT)。然而，定量TL-201 SPECT 尚未充分发挥其潜力，因为物理性能不佳 TL-201药剂的特性。最近，~(99m)Tm被标记 开发了甲氧基异丁基异腈(TC-MIBI)，它避免了 TL-201的大部分不利特性。总的目标是 这项提案旨在开发、验证和评估一种 无创性定量评价心肌血流灌注的方法 使用Tc-MIBI SPECT。这一总体目标分成两个独立的部分 横断面。I.心肌灌注量的相对定量：长期 本部分的目标是开发、优化和验证 采集、过滤、重建、定量分析和 显示TC-MIBI SPECT数据。需要检验的假设是 相对定量(异常灌注量的测定 心肌)的TC-MIBI SPECT数据可以在#年的患者研究中实施 一种他们将更准确地预测定量冠状动脉的方式 血管造影所见及灌注缺损区的存在和大小。二、 心肌血流灌注的绝对定量：的长期目标 这一部分是为了开发在临床环境中获得 像素计数值与心肌示踪剂的线性关系 浓度，从而获得真正的定量成像。这应该是 从而改善了正常组织计数分布的一致性， 增强病变对比度和测量实际心肌血流量。 为了实现这一目标，有必要进行纠正。 适用于：康普顿散射、心肌衰减和对象大小 有限分辨率效应。