QUANTITATION OF MYOCARDIAL PERFUSION BY TC-99M-MIBI

T1-201心肌灌注闪烁扫描已广泛用于非心脏病 冠状动脉疾病（CAD）的侵入性评价。广泛的研究 我们和其他人的发展导致了 图像分析和单光子发射的客观方法 计算机断层扫描（SPECT）。尽管如此，定量Tl-201 SPECT 尚未充分发挥其潜力，因为次优的物理 T1 -201的特点。最近，标记的锝-99m 已经开发了甲氧基异丁基异腈（Tc-MIBI）， Tl-201的大部分不利特性。的总体目标 该提案旨在开发、验证和评估 无创性心肌灌注定量评价方法 使用Tc-MIBI SPECT。这一总体目标在两个单独的 路段I.心肌灌注的相对定量：长期 本节的目的是开发、优化和验证以下方法： 采集、过滤、重建、定量分析，以及 显示Tc-MIBI SPECT数据。有待检验的假设是， 相对定量（测定异常灌注的体积） 心肌）的Tc-MIBI Spect数据可以在患者研究中实现， 他们将更准确地预测定量冠状动脉 血管造影结果以及灌注缺损的存在和大小。二. 心肌灌注的绝对定量： 本节旨在开发方法，以在临床环境中获得 像素计数值与心肌示踪剂之间的线性关系 浓度，从而获得真正的定量成像。这应该 导致正常组织计数分布的均匀性提高， 增加病变对比度和测量实际心肌血流量。 为了实现这一目标，有必要进行校正 用于：康普顿散射、心肌的衰减和对象大小， 有限分辨率效应

T1-201 myocardial perfusion scintigraphy has been widely utilized for non- invasive evaluation of coronary artery disease (CAD). Extensive research and development by our group and others has resulted in the development of objective methods for analysis of images and single photon emission computerized tomography (SPECT). Nevertheless, quantitative Tl-201 SPECT has not yet reached its full potential because of suboptimal physical characteristics of the Tl-201 agent. Recently, Technetium-99m labeled Methoxy Isobutyl Isonitrile (Tc-MIBI) has been developed which obviates most of the unfavorable characteristics of Tl-201. The overall objective of this proposal is to develop, validate and assess clinical applications of a noninvasive method for quantitative assessment of myocardial perfusion using Tc-MIBI SPECT. This overall objective is addressed in two separate sections. I. Relative Quantitation of Myocardial Perfusion: The long term objective of this section is to develop, optimize and validate methods for acquisition, filtering, reconstruction, quantitative analysis, and displaying Tc-MIBI SPECT data. The hypothesis to be tested is whether relative quantitation (determination of the volume of abnormally perfused myocardium) of Tc-MIBI Spect data can be implemented in patient studies in a manner in which they will more accurately predict quantitative coronary angiographic findings and the presence and size of perfusion defects. II. Absolute Quantitation of Myocardial Perfusion: The long-term objective of this section is to develop methods to obtain, in the clinical setting, a linear relation between pixel count values and myocardial tracer concentrations and thus obtain truly quantitative imaging. This should result in improved uniformity of normal tissue count distribution, increased lesion contrast and measurement of actual myocardial blood flow. On order to fulfill this objective it is necessary to apply corrections for: Compton Scatter, attenuation and object size of the myocardium due to finite resolution effects.