THROMBOLYSIS IN MI (TIMI) II FOLLOW-UP
MI (TIMI) II 随访中的溶栓
基本信息
- 批准号:3359154
- 负责人:
- 金额:$ 131.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-07-01 至 1991-11-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Thrombolysis in Myocardial Infarction (TIMI) Phase II study is
designed to determine whether intravenous thrombolytic therapy
given in the early hours of acute myocardial infarction should be
followed by percutaneous transluminal coronary angioplasty
(PTCA). All patients are treated with recombinant tissue
plasminogen activator (rt-PA) within four hours of the onset of
symptoms of acute myocardial infarction. In one group of TIMI
Clinical Centers patients are randomized to rt-PA alone or to one
of two groups with PTCA to be performed either two hours or 18
to 48 hours after the start of the rt-PA infusion. In all other TIMI
Clinical Centers patients are randomized to rt-PA alone or rt-PA
plus 18 to 48-hour PTCA. In addition in these latter Clinical
Centers all patients who are eligible for the initiatin of beta-
blocker therapy are randomized to either immediate or deferred
beta-blocker therapy. Patient recruitment for Phase II started in
April 1986 and as of September 30, 1987 a total of 2,351 patients
had been enrolled. The recruitment goal is 4,000 patients by the
end of June 1988.
Current funding for all centers except the Coordination Center
and Coagulation Core laboratory will end September 30, 1988.
Funding for the Coordinating Center will end September 30, 1989
and funding for the coagulation Core Laboratory will end in
September 30, 1991. The available Clinical Center funds will
provide for patient follow-up through August 1988 so that all
patients will be followed through six weeks but only half of the
patients will have completed the one year follow-up examination
specified in the Protocol. The purpose of this application is to
obtain support to (1) complete one year follow-up as outlined in
the TIMI II Protocol on all patients enrolled, with telephone
contacts at three and six months and an examination including
treadmill exercise test at one year; (2) maintain annual follow-up
of all patients for a minimum of three years; (3) continue the
activity of the TIMI investigators in using the extensive TIMI data
bank to prepare study reports for publication; and (4) provide
assistance to TIMI investigators in the analysis of ancillary
studies.
心肌梗死溶栓(TIMI) II期研究是
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Genell L Knatterud其他文献
Genell L Knatterud的其他文献
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{{ truncateString('Genell L Knatterud', 18)}}的其他基金
THROMBOLYSIS IN MYOCARDIAL ISCHEMIA COORDINATING CENTER
心肌缺血协调中心的溶栓
- 批准号:
3360642 - 财政年份:1989
- 资助金额:
$ 131.45万 - 项目类别:
THROMBOLYSIS IN MYOCARDIAL ISCHEMIA COORDINATING CENTER
心肌缺血协调中心的溶栓
- 批准号:
3360643 - 财政年份:1989
- 资助金额:
$ 131.45万 - 项目类别:
THROMBOLYSIS IN MYOCARDIAL ISCHEMIA COORDINATING CENTER
心肌缺血协调中心的溶栓
- 批准号:
3360644 - 财政年份:1989
- 资助金额:
$ 131.45万 - 项目类别:
THROMBOLYSIS IN MYOCARDIAL ISCHEMIA COORDINATING CENTER
心肌缺血协调中心的溶栓
- 批准号:
3360645 - 财政年份:1989
- 资助金额:
$ 131.45万 - 项目类别:
THROMBOLYSIS IN MYOCARDIAL ISCHEMIA COORDINATING CENTER
心肌缺血协调中心的溶栓
- 批准号:
3360640 - 财政年份:1989
- 资助金额:
$ 131.45万 - 项目类别: