TECHNIQUES FOR DETECTION OF LESIONS IN CORONARY ARTERIES

冠状动脉病变检测技术

• 批准号: 3356169
• 负责人: HOWARD L KANTOR
• 金额: $ 39.93万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-01 至 1992-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3356169
• 关键词: angiography; antihyperlipoproteinemic agent; artery stenosis; atherosclerosis; blood flow measurement; cardiography; cardiovascular disorder diagnosis; contrast media; coronary artery; coronary occlusion /thrombosis; densitometry; diagnostic catheterization; dipyridamole; disease /disorder proneness /risk; heart circulation; heart transplantation; histopathology; human subject; human tissue; image enhancement; image processing; interferometry; lipids; longitudinal human study; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; phantom model; polyvinyls; radionuclide diagnosis; vascular resistance; vasomotion

This grant proposal addresses the non-invasive evaluation of coronary stenoses using Nuclear Magnetic Resonance imaging techniques. We will evaluate and improve several imaging methods to both directly measure and discern the effects of coronary stenoses. These methods include: standard spin-echo NMR imaging and viewing angle correction to image large portions of the coronary anatomy; flow velocity multi-dimensional imaging limited slice-selective 3D NMR angiography; slice- selective 2D projected NMR angiography; time-of-flight NMR imaging. Besides examination of the coronary vessel to determine the patent lumen, we will also be detecting and quantitating the atheroma in the coronary wall. We will evaluate these techniques in the following systems: a) a phantom 2-5 mm polyvinyl chloride tubing model of coronary stenosis with pulsatile flow and associated with a model of respiratory related motion, b) a porcine model of coronary atherogenesis allowing the longitudinal examination of coronary anatomy by cardiac catheterization and NMR non-invasive techniques as well as the single time point comparison of these methods with pathologic corroboration, c) the examination of human subjects who have undergone x-ray coronary angiography to compare results with this standard clinical x-ray modality, as well as the examination of human subjects who are scheduled to undergo cardiac transplantation for direct comparison of NMR determined coronary stenoses with pathologic specimens. We address the major limitations of NMR imaging for the observation of coronary anatomy which include limitations of resolution and signal-to-noise. We will be implementing variations of standard NMR sequences to reduce these limitations and will utilize methods of post-processing resolution enhancement to bring out the detail of coronary atheromata. As part of our atheroma detection protocol, we will use NMR microscopic techniques to improve the specifically and sensitivity of our measurements. We will also examine the utility of NMR as a measure of the flow limiting character of coronary stenoses by performing measurements before and after the administration of dipyridamole to our porcine model. Changes in flow in this system will be monitored with the radioactive microsphere blood flow method.

该赠款提案涉及对 使用核磁共振成像的冠状瓣 技术。 我们将评估并改进几个成像 直接测量和辨别的方法 冠状动脉。 这些方法包括：标准自旋回波 NMR成像和视角校正图像大图 冠状动脉解剖的一部分；流速多维 成像有限的切片选择性3D NMR血管造影；片- 选择性2D投影NMR血管造影；飞行时间NMR 成像。 除了检查冠状血管以确定 专利管腔，我们还将检测和定量 冠状动脉壁中的动脉瘤。 我们将评估这些技术 在以下系统中：a）幻影2-5 mm聚氯乙烯 冠状动脉狭窄的管道模型随脉动流动和 与呼吸相关运动模型相关，b）a 冠状动脉粥样硬化的猪模型允许纵向 通过心脏导管插入术和检查冠状动脉解剖结构 NMR非侵入技术以及单个时间点 这些方法与病理佐证的比较，c） 检查经历X射线的人类受试者 冠状动脉造影将结果与此标准进行比较 临床X射线形态以及对人类的检查 计划接受心脏移植的受试者 直接比较NMR确定的冠状动脉stenose与 病理标本。 我们解决了NMR成像的主要局限性 观察冠状动脉解剖结构，包括 分辨率和信噪比。 我们将实施 标准NMR序列的变化以减少这些限制 并将利用后处理方法的方法 增强以提出冠状动脉瘤细节。 作为我们动脉瘤检测方案的一部分，我们将使用NMR 微观技术以提高特定和灵敏度 我们的测量。 我们还将研究NMR的实用性 通过 在给药之前和之后进行测量 二吡啶胺至我们的猪模型。 流动的变化 系统将用放射性微球血液监测 流量法。