Hyper-domain luminescence lifetime imaging for mapping molecular dynamics

用于绘制分子动力学的超域发光寿命成像

• 批准号: DE170100821
• 负责人: Dr Yiqing Lu
• 金额: $ 26.66万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-02-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100821
• 关键词: Hyper; domain; luminescence; lifetime; imaging

This project aims to enable lifetime-multiplexed optical imaging of molecular dynamics of biological systems in real time. The grand challenge of modern life sciences is to understand the molecular origins of complex processes. Using lifetime measurement, this project will realise highly-multiplexed real-time luminescence imaging with simultaneous ultrahigh detection sensitivity and spatial resolution. By generating fresh insights into molecular fingerprints of relevance for future disease diagnostics and treatment, the project outcomes are expected to consolidate Australia’s leading position in the health sciences. Upon commercialisation, the intellectual property is expected to generate considerable economic returns.

该项目旨在实现生物系统分子动力学的实时多重光学成像。现代生命科学的巨大挑战是了解复杂过程的分子起源。通过寿命测量，该项目将实现高度多路复用的实时发光成像，同时具有超高的检测灵敏度和空间分辨率。通过对与未来疾病诊断和治疗相关的分子指纹产生新的见解，该项目的成果预计将巩固澳大利亚在健康科学领域的领先地位。知识产权商业化后有望产生可观的经济回报。