CARDIAC ASSESSMENT IN ANESTHESIA BY 3D MEASUREMENT

通过 3D 测量进行麻醉中的心脏评估

• 批准号: 3359206
• 负责人: ROY W MARTIN
• 金额: $ 17.39万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3359206
• 关键词: anesthetics; angiocardiography; dogs; drug adverse effect; heart contraction; heart disorder diagnosis; heart function; heart pharmacology; human subject; indicator dilution test; intracardiac pressure; intracardiac volume; myocardial ischemia /hypoxia; myocardium disorder; noninvasive diagnosis; online computer; ultrasound blood flow measurement

We have developed a new, relatively noninvasive-method of quantitatively studying the heart which provides measures of left- ventricular (LV) end-diastolic volume, end-systolic volume, ejection fraction (EF), stroke volume (SV), and cardiac output (CO). Our studies in dogs comparing ultrasonic determinations by this method to those made using conventional radionuclide and thermal dilution techniques have been found to be in close agreement. This agreement is equivalent to results found when other commonly used clinical methods are compared. Furthermore, with little change in protocol and development of some additional processing algorithms several other cardiac measures can be made. Our major purpose of the proposed research is to investigate these additional measures. First, we will study the assessment of cardiac function by using end-diastolic and end-systolic volumes and pressures, taken under different conditions of preload and afterload. The relationships between these variables at end- diastole will give compliance, a measure of cardiac diastolic performance, while regression analysis of the pressure-volume curve at end-systole provides for measuring contractility. These measures should be useful to study the deleterious effects of anesthetics on the heart and the benefitical effects of inotropes and other drugs used during surgery. Next, we plan to utilize the 3-D information we acquire of LV borders by our method, to investigate regional measures of cardiac function. We propose to calculate and display regional EF and regional wall motion, not just of a single plane, but of the entire LV wall. We will study these new measures in an acute animal model of myocardial ischemia and in two surgical human populations: a group with normal hearts and a group with documented persistent regional wall motion abnormalities. The results of the study will determine whether the methodology is suitable for clinical investigation and ultimately if incorporated into real time analysis would it be useful in patient management.

我们已经开发了一种新的，相对非侵入性的-方法 定量研究心脏，提供左-左-心的测量 心脏(LV)舒张末容量、收缩末期容量、 射血分数(EF)、每搏量(SV)和心输出量 (Co)。我们在狗身上的研究比较了超声检测和 这种方法比使用常规放射性核素和 热稀释技术已被发现接近成功。 协议。本协议等同于在以下情况下发现的结果 并对其他常用的临床方法进行了比较。此外， 在协议上几乎没有变化，并开发了一些额外的 处理算法可以进行其他几种心脏测量。 我们建议的研究的主要目的是调查这些 其他措施。首先，我们将研究评估 用舒张末和收缩末期容量评价心功能 和压力，在不同的预加载和压力条件下 后装。这些变量之间的关系在末期- 舒张期将产生顺应性，这是心脏舒张期的一种衡量标准 性能，同时对压力-体积曲线进行回归分析 收缩末期提供了测量收缩能力的条件。这些 采取的措施应该有助于研究 麻醉药对心脏的作用及肌松药的有益作用 以及手术期间使用的其他药物。 接下来，我们计划利用我们从LV获得的3D信息 边界由我们的方法，调查心脏的区域性措施 功能。我们建议计算和显示区域EF和 区域性墙体运动，不仅是单个平面的运动，而且是整个 LV墙。我们将在一个急性动物模型中研究这些新措施。 在两个外科人群中：A 一组心脏正常，一组有记录的持续性 节段性室壁运动异常。该研究的结果将 确定方法学是否适用于临床 调查，并最终如果纳入实时 分析它在病人管理中是否有用。