STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE

梗死左心室的结构和功能

• 批准号: 3361346
• 负责人: Nathaniel REICHEK
• 金额: $ 44.86万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3361346
• 关键词: cineangiocardiography; diagnosis quality /standard; dogs; echocardiography; heart dimension /size; heart disorder diagnosis; heart motion; heart ventricle; human subject; magnetic resonance imaging; myocardial infarction; myocardial ischemia /hypoxia; scars

We hypothesize that: 1) SPATIAL MODULATION OF MAGNETIZATION (SPAMM), a new ECG gated spin echo magnetic resonance "tagging" method for tracking fixed points in the myocardium, can depict local motion and deformation of normal, ischemia and infarcted myocardium;2) Analysis of left ventricular structure and function in ischemic heart disease can be enhanced using three-dimensional reconstruction and quantitative analysis of SPAMM images. Therefore, we will complete tasks in three areas: Analytic tools will be developed for: a) automated tracking of myocardial "tags", b) quantitation of regional dimensions in surface displays and grey scale data volumes, and c) measurement of cardiac deformation. Canine experiments (n=36) will assess left ventricular structure and function before and after creation of acute ischemia or chronic infraction. Since most in vivo imaging methods cannot track fixed points, our primary validation approach will be comparison to sonomicrometry segment length, with secondary comparisons to pathologic size and shape of nonperfused regions and scars. Human studies will examine 60 patients with recent or old infraction with comparison to biplane contrast ventriculography and two-dimensional echocardiography. Results will provide powerful new tools for assessment of left ventricular structure and function and new information about local deformation of normal, ischemic and infarcted myocardium.

我们假设：1)空间调制的磁化（SPAMM），一个新的