STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE

梗死左心室的结构和功能

• 批准号: 3361348
• 负责人: Nathaniel REICHEK
• 金额: $ 42.1万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3361348
• 关键词: cineangiocardiography; diagnosis quality /standard; dogs; echocardiography; heart dimension /size; heart disorder diagnosis; heart motion; heart ventricle; human subject; magnetic resonance imaging; myocardial infarction; myocardial ischemia /hypoxia; scars

We hypothesize that: 1) SPATIAL MODULATION OF MAGNETIZATION (SPAMM), a new ECG gated spin echo magnetic resonance "tagging" method for tracking fixed points in the myocardium, can depict local motion and deformation of normal, ischemia and infarcted myocardium;2) Analysis of left ventricular structure and function in ischemic heart disease can be enhanced using three-dimensional reconstruction and quantitative analysis of SPAMM images. Therefore, we will complete tasks in three areas: Analytic tools will be developed for: a) automated tracking of myocardial "tags", b) quantitation of regional dimensions in surface displays and grey scale data volumes, and c) measurement of cardiac deformation. Canine experiments (n=36) will assess left ventricular structure and function before and after creation of acute ischemia or chronic infraction. Since most in vivo imaging methods cannot track fixed points, our primary validation approach will be comparison to sonomicrometry segment length, with secondary comparisons to pathologic size and shape of nonperfused regions and scars. Human studies will examine 60 patients with recent or old infraction with comparison to biplane contrast ventriculography and two-dimensional echocardiography. Results will provide powerful new tools for assessment of left ventricular structure and function and new information about local deformation of normal, ischemic and infarcted myocardium.

我们假设：1）空间调制反垃圾邮件（SPAMM），一个新的 心电门控自旋回波磁共振“标记”方法跟踪固定 心肌中的点，可以描绘局部运动和变形， 正常、缺血和梗死心肌;2）左心室 缺血性心脏病的结构和功能可以通过使用 SPAMM图像的三维重建和定量分析。 因此，我们将在三个方面完成任务：分析工具将 开发用于：a）自动跟踪心肌“标签”，B）定量 表面显示和灰度数据量中的区域尺寸，以及 c）测量心脏变形。 犬实验（n=36）将 评估左心室结构和功能的创建前后 急性缺血或慢性梗塞的症状由于大多数体内成像方法 无法跟踪固定点，我们的主要验证方法将是 与超声测微法节段长度的比较，以及与 非灌注区域和瘢痕的病理大小和形状。 人类研究 将检查60名近期或既往有违规行为的患者， 双平面对比心室造影和二维超声心动图。 结果将为评价左心室功能提供有力的新工具 结构和功能以及局部变形的新信息 正常、缺血和梗死心肌。