STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE

我们假设：1)磁化强度的空间调制(Spamm)，一种新的 心电门控自旋回波磁共振“标记法”跟踪固定 心肌中的点，可以描绘局部的运动和变形 正常、缺血和梗死心肌；2)左心功能分析 可以增强缺血性心脏病的结构和功能 Spamm图像的三维重建和定量分析。 因此，我们将在三个方面完成任务：分析工具将 开发的目的是：a)自动跟踪心肌“标签”，b)定量 表面显示和灰度级数据体中的区域维度，以及 C)心脏变形的测量。犬类实验(n=36)将 评价手术前后的左心室结构和功能 急性脑缺血或慢性脑梗塞。由于大多数活体成像方法 无法跟踪固定点，我们的主要验证方法将是 与声波测微仪片段长度的比较，以及与 无灌注区和瘢痕的病理大小和形状。人文科学 将检查60名近期或陈旧性心肌梗死的患者，并与 双平面声学造影术和二维超声心动图。 研究结果将为左心功能的评估提供强有力的新工具 结构与功能及局部变形的新信息 正常、缺血和梗死心肌。

We hypothesize that: 1) SPATIAL MODULATION OF MAGNETIZATION (SPAMM), a new ECG gated spin echo magnetic resonance "tagging" method for tracking fixed points in the myocardium, can depict local motion and deformation of normal, ischemia and infarcted myocardium;2) Analysis of left ventricular structure and function in ischemic heart disease can be enhanced using three-dimensional reconstruction and quantitative analysis of SPAMM images. Therefore, we will complete tasks in three areas: Analytic tools will be developed for: a) automated tracking of myocardial "tags", b) quantitation of regional dimensions in surface displays and grey scale data volumes, and c) measurement of cardiac deformation. Canine experiments (n=36) will assess left ventricular structure and function before and after creation of acute ischemia or chronic infraction. Since most in vivo imaging methods cannot track fixed points, our primary validation approach will be comparison to sonomicrometry segment length, with secondary comparisons to pathologic size and shape of nonperfused regions and scars. Human studies will examine 60 patients with recent or old infraction with comparison to biplane contrast ventriculography and two-dimensional echocardiography. Results will provide powerful new tools for assessment of left ventricular structure and function and new information about local deformation of normal, ischemic and infarcted myocardium.