STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE
STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE
批准号:
3361348
负责人:
Nathaniel REICHEK
金额:
$42.1万
依托单位国家:
美国
项目类别:
财政年份:
1990
资助国家:
美国
项目状态:
已结题
起止时间:
1990-04-01 至 1993-03-31
中文摘要
我们假设:1)磁化空间调制(SPAMM),一种新的
用于跟踪固定的心电图门控自旋回波磁共振“标记”方法
心肌中的点,可以描绘局部运动和变形
正常、缺血、梗死心肌;2)左心室分析
可以使用以下方法增强缺血性心脏病的结构和功能
SPAMM图像的三维重建和定量分析。
因此,我们将完成三个方面的任务: 分析工具将
开发用于:a) 自动跟踪心肌“标签”,b) 定量
表面显示和灰度数据体中的区域尺寸,以及
c) 心脏变形的测量。 犬类实验 (n=36) 将
评估左心室创建前后的结构和功能
急性缺血或慢性梗塞。由于大多数体内成像方法
无法跟踪固定点,我们的主要验证方法是
与声测法段长度的比较,以及与
非灌注区域和疤痕的病理大小和形状。 人类研究
将检查 60 名近期或旧有梗塞的患者,并与
双平面造影心室造影和二维超声心动图。
结果将为评估左心室提供强大的新工具
结构与功能以及局部变形的新信息
正常、缺血和梗塞心肌。
英文摘要
We hypothesize that: 1) SPATIAL MODULATION OF MAGNETIZATION (SPAMM), a new
ECG gated spin echo magnetic resonance "tagging" method for tracking fixed
points in the myocardium, can depict local motion and deformation of
normal, ischemia and infarcted myocardium;2) Analysis of left ventricular
structure and function in ischemic heart disease can be enhanced using
three-dimensional reconstruction and quantitative analysis of SPAMM images.
Therefore, we will complete tasks in three areas: Analytic tools will be
developed for: a) automated tracking of myocardial "tags", b) quantitation
of regional dimensions in surface displays and grey scale data volumes, and
c) measurement of cardiac deformation. Canine experiments (n=36) will
assess left ventricular structure and function before and after creation
of acute ischemia or chronic infraction. Since most in vivo imaging methods
cannot track fixed points, our primary validation approach will be
comparison to sonomicrometry segment length, with secondary comparisons to
pathologic size and shape of nonperfused regions and scars. Human studies
will examine 60 patients with recent or old infraction with comparison to
biplane contrast ventriculography and two-dimensional echocardiography.
Results will provide powerful new tools for assessment of left ventricular
structure and function and new information about local deformation of
normal, ischemic and infarcted myocardium.
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会议论文
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR
-
批准号:6024175
-
项目类别:
-
资助金额:$33.53万
-
财政年份:1996
-
负责人:Nathaniel REICHEK
-
依托单位:
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR
-
批准号:6348787
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1996
-
负责人:Nathaniel REICHEK
-
依托单位:
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR
-
批准号:6383844
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1996
-
负责人:Nathaniel REICHEK
-
依托单位:
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR
-
批准号:2707793
-
项目类别:
-
资助金额:$33.84万
-
财政年份:1996
-
负责人:Nathaniel REICHEK
-
依托单位:
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR
-
批准号:2649632
-
项目类别:
-
资助金额:$2.81万
-
财政年份:1996
-
负责人:Nathaniel REICHEK
-
依托单位:
EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR
-
批准号:2318129
-
项目类别:
-
资助金额:$32.52万
-
财政年份:1996
-
负责人:Nathaniel REICHEK
-
依托单位:
STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE
-
批准号:3361349
-
项目类别:
-
资助金额:$13.2万
-
财政年份:1990
-
负责人:Nathaniel REICHEK
-
依托单位:
STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE
-
批准号:3361346
-
项目类别:
-
资助金额:$44.86万
-
财政年份:1990
-
负责人:Nathaniel REICHEK
-
依托单位:
STRUCTURE AND FUNCTION OF INFARCTED LEFT VENTRICLE
-
批准号:2220772
-
项目类别:
-
资助金额:$30.78万
-
财政年份:1990
-
负责人:Nathaniel REICHEK
-
依托单位: