Creativity@Home - Designer magnetic particle tagging and activation of mechano-sensitive receptors for remote control of cell signalling and behaviour

Creativity@Home - 设计师磁性粒子标记和机械敏感受体的激活，用于远程控制细胞信号传导和行为

• 批准号: EP/I032002/1
• 负责人: Alicia El Haj
• 金额: $ 13万
• 依托单位: Keele University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FI032002%2F1
• 关键词: Creativity; Home; Designer; magnetic; particle

A recent major catalyst in aiding us to understand how cells respond to mechanical environment has been the advances in cell and tissue engineering and the regenerative medicine field. With the strong multidisciplinary framework for this field, we have been able to advance the potential for using tissue mechanics in defining how we grow and repair tissues. Alongside this we can ask basic questions about mechanotransduction which allows us to address major questions in this field. Seeking new therapies for regenerative medicine treatments has led to the utilisation of cells, in particular stem cells, for repair and replacement tissues. The use of living cells as a therapy presents several challenges; the most focal one being how to control therapeutic cells in the body. In our lab, we have established 2D and 3D tissue engineering models which allow us to develop therapies for regenerative medicine but also enable us to create more biological models for testing and understanding the role of mechanics in tissue biology and pathology. We have developed magnetic nanoparticle based strategies for tagging cell receptors and controlling cell behaviour and mechnotransduction. This project allows us to research into new multidisciplinary methods for specific magnetic particle tagging of cell mechano-sensitive receptors present internally and externally in a cell.

最近的一个主要催化剂，帮助我们了解细胞如何响应机械环境一直在细胞和组织工程和再生医学领域的进展。凭借该领域强大的多学科框架，我们已经能够推进使用组织力学来定义我们如何生长和修复组织的潜力。除此之外，我们可以问一些关于机械转导的基本问题，这使我们能够解决这个领域的主要问题。寻求再生医学治疗的新疗法已经导致利用细胞，特别是干细胞来修复和替换组织。使用活细胞作为治疗提出了几个挑战;最焦点的一个是如何控制体内的治疗细胞。在我们的实验室中，我们建立了2D和3D组织工程模型，使我们能够开发再生医学的疗法，同时也使我们能够创建更多的生物模型，用于测试和理解力学在组织生物学和病理学中的作用。我们已经开发了基于磁性纳米颗粒的标记细胞受体和控制细胞行为和mechnotransduction的策略。该项目使我们能够研究新的多学科方法，用于对细胞内和细胞外存在的细胞机械敏感受体进行特异性磁性颗粒标记。

项目成果

Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics.

• DOI: 10.3390/ijms231710164
• 发表时间: 2022-09-05
• 期刊: International journal of molecular sciences
• 影响因子: 5.6

Translation of remote control regenerative technologies for bone repair.

• DOI: 10.1038/s41536-018-0048-1
• 发表时间: 2018
• 期刊: NPJ Regenerative medicine
• 影响因子: 7.2
• 作者: Markides H;McLaren JS;Telling ND;Alom N;Al-Mutheffer EA;Oreffo ROC;Zannettino A;Scammell BE;White LJ;El Haj AJ
• 通讯作者: El Haj AJ

Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis.

• DOI: 10.1155/2017/2905104
• 发表时间: 2017
• 期刊: Stem cells international
• 影响因子: 4.3
• 作者: Chapman V;Markides H;Sagar DR;Xu L;Burston JJ;Mapp P;Kay A;Morris RH;Kehoe O;El Haj AJ
• 通讯作者: El Haj AJ