PANIC, AVOIDANCE AND THE VESTIBULAR SYSTEM

恐慌、回避和前庭系统

• 批准号: 3379135
• 负责人: ROLF G JACOB
• 金额: $ 19.91万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-01-01 至 1995-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3379135
• 关键词: anxiety; anxiety disorders; audiometry; avoidance behavior; balance; binaural hearing; brain electrical activity; evoked potentials; eye movements; head movements; human subject; hyperpnea; labyrinth disorder; mental disorder diagnosis; motion perception; nystagmus; panic disorder; perceptual maskings; phobias; posture; proprioception /kinesthesia; psychological tests; psychosomatic disorders; vestibular apparatus; vestibular pathway; vestibuloocular reflex; visual perception

This study concerns Panic Disorder with or without Agoraphobia, conditions associated with intense discomfort and significant social incapacitation. Results from our laboratory indicate an association between agoraphobia and impaired vestibular function. Agoraphobics showed evidence for greater reliance on visual or proprioceptive cues to maintain balance. The results also indicated subclinical abnormalities on audiological test of brainstem function in anxiety disorders, but these abnormalities did not specifically occur in agoraphobia. The purpose of the proposed research is to replicate these findings and continue research begun during the previous funding period examining psychosomatic mechanisms in vestibular dysfunction. Otoneurological function will be studied in the following diagnostic groups: (1) Panic disorder (uncomplicated); (3) Panic disorder with Agoraphobia; (3) Non-panic anxiety disorder without agoraphobia-like avoidance; and (4) healthy Normal controls. Thirty subjects in each group will receive a battery of clinical audiological and vestibular tests. Normal control subjects will also undergo a test for the effect of hyperventilation on vestibular function. Physiological and self- report measures of anxiety during vestibular testing will be obtained and examined for covariation with vestibular test results. The evaluators of the audiological and vestibular tests will be blind as to the subject's diagnoses. The results of the vestibular and audiological tests will be examined with respect to prevalence of clinically abnormal findings. Parametric analysis will test for systematic differences between groups over the entire normal and abnormal range. The results of the study will have implications for our understanding of the pathogenesis of these disorders and to the development of enhanced treatments.

这项研究涉及伴有或不伴有广场恐惧症的恐慌症， 与强烈不适和显着社交相关的情况 丧失行为能力。 我们实验室的结果表明存在关联 广场恐惧症和前庭功能受损之间的关系。 广场恐惧症 有证据表明，人们更多地依赖视觉或本体感觉线索 保持平衡。 结果还表明亚临床异常 焦虑症脑干功能的听力学测试，但是 这些异常并没有专门发生在广场恐惧症中。 这 拟议研究的目的是复制这些发现并 继续在上一个资助期间开始的研究 前庭功能障碍的心身机制。 将在以下诊断中研究耳神经功能 组别： (1) 惊恐障碍（简单）； (3) 惊恐障碍 广场恐惧症； (3) 不具有广场恐怖症样特征的非惊恐性焦虑症 回避； (4) 健康正常对照。 每门三十个科目 小组将接受一系列临床听力和前庭检查 测试。 正常对照受试者也将接受效果测试 过度换气对前庭功能的影响。 生理和自我 将获得前庭测试期间焦虑的报告测量值，并且 检查与前庭测试结果的协变。 评估者 听力学和前庭测试对于受试者的情况将是盲目的 诊断。 前庭和听力测试的结果将是 检查临床异常发现的发生率。 参数分析将测试组之间的系统差异 在整个正常和异常范围内。 研究结果将 对我们理解这些疾病的发病机制具有重要意义 疾病和增强治疗的发展。