Fast three-dimensional imaging of neural signal propagation using light-field microscopy

使用光场显微镜对神经信号传播进行快速三维成像

• 批准号: DE170100319
• 负责人: Dr Michael Taylor
• 金额: --
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2017-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100319
• 关键词: Fast; three; dimensional; imaging; neural

This project aims to use a light-field microscope to reveal the dynamics of sustained neural activity in the brain. The brain’s neurons are highly interconnected, so neural signals can be sustained in a repeating cycle. While this may underlie tasks such as working memory, its role in information processing is unclear. Understanding information processing is vital for finding treatments for neurodegenerative disorders. To characterise this large-scale aspect of neural computation, this project measures neural activity at high speed across large numbers of neurons. This is expected to provide evidence of the nature of sustained activity which may in the future lead to treatments for neurodegenerative disorders.

该项目旨在使用光场显微镜来揭示大脑中持续神经活动的动力学。大脑的神经元高度相互连接，因此神经信号可以在重复的循环中保持不变。虽然这可能是工作记忆等任务的基础，但它在信息处理中的作用尚不清楚。了解信息处理对于寻找神经退行性疾病的治疗方法至关重要。为了描述神经计算的这一大规模方面，该项目测量了大量神经元的高速神经活动。预计这将为持续活动的性质提供证据，这可能会在未来导致神经退行性疾病的治疗。