CHILDREN AT RISK FOR DEPRESSION

面临抑郁风险的儿童

• 批准号: 3378006
• 负责人: ROBERT J. REICHLER
• 金额: $ 22.77万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-02-15 至 1989-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3378006
• 关键词: adolescence (12-20); autonomic disorder; behavior disorders; catecholamines; child (0-11); child mental disorders; clinical anxiety; cortisol; depression; disease /disorder proneness /risk; early diagnosis; family structure /dynamics; human subject; mental disorder diagnosis; mental disorder prevention; mental health epidemiology; personality disorders; psychophysiology; urinalysis

Despite evidence for a familial pattern of transmission and recent studies of depression in children, the relationship between depression in children and adults has not been systematically or prospectively investigated, and is not well understood. In addition, there is a very large overlap in the symptomatology of depression and anxiety disorders in both children and adults. These factors have impaired the ability for early identification and prevention of the development of serious depression in children and adults. The confusion between anxiety disorders and depression has also clouded efforts to identify specific etiological and pathological processes. The purpose of this study is to identify a cohort of children and adolescents who are at significant risk for developing major depressive disorders. This study will compare and differentiate children at risk for depression from those at risk for anxiety disorders. We will define the specific expression of this risk for depression and identify critical factors in the development of the disorder. In addition to their major diagnosis, we will identify specific personality and behavioral characteristics of the parents and children which affect the development of psychopathology and depression in the children. Family environmental and biological factors which may affect or differentiate the risk for depression in children will also be studied. Depressed adults from a clinic for depression and anxiety disorders, and their children will be evaluated. Diagnostic, personality and behavioral measures will be used in assessing both depressive and anxiety characteristics in order to compare them to children at risk for anxiety disorders and to normal controls. Platelet MAO and 24-hour urinary catecholamines will be measured in all subjects. Temperature circadian rhythms and GSR studies will also be completed on all subjects. A subsample of subjects will also have salivary dexamethasone suppresison tests, echocardiagrams and exercise tolerance tests. A subset of parents will additionally receive lactate infusions to assess their vulnerability to panic attacks. The results of these studies will provide critical information to improve the definition and differentiation of depression and anxiety disorders, and lead to enhanced ability for early identification of children at risk for depression. This will improve the potential for prevention of these disorders and facilitate efforts to identify specific etiological factors.

尽管有证据表明传播的家族模式和最近的研究 儿童抑郁症，儿童抑郁之间的关系 成年人尚未进行系统或前瞻性调查，并且 不太了解。 此外，在 儿童抑郁和焦虑症的症状学和 成年人。 这些因素损害了早期识别的能力 预防儿童严重抑郁症的发展 成年人。 焦虑症与抑郁症之间的混乱也有 识别特定病因和病理学的乌云努力 过程。 这项研究的目的是确定一群儿童 以及有巨大抑郁症的巨大风险的青少年 疾病。 这项研究将比较并区分有风险的儿童 患有焦虑症风险的抑郁症。 我们将定义 这种抑郁症风险的具体表达并确定关键 疾病发展的因素。 除了他们的专业 诊断，我们将确定特定的个性和行为 影响发展发展的父母和孩子的特征 儿童的心理病理学和抑郁症。 家庭环境和 可能影响或区分风险的生物因素 还将研究儿童的抑郁症。 沮丧的成年人 抑郁症和焦虑症的诊所，他们的孩子将是 评估。 诊断，个性和行为措施将用于 评估抑郁和焦虑特征以比较 他们面向有焦虑症和正常控制风险的儿童。 毛毛血小板和24小时的尿尿酚胺将在所有人中测量 主题。 温度昼夜节律和GSR研究也将是 在所有主题上完成。 受试者的子样本也将有唾液 地塞米松替补测试，超声心动图和运动耐受性 测试。 父母的一部分还将收到乳酸输注 评估他们对惊恐发作的脆弱性。 这些研究的结果将提供关键信息以改进 抑郁和焦虑症的定义和区分，以及 提高了早期确定有风险的儿童的能力 沮丧。 这将提高预防这些预防的潜力 疾病并促进识别特定病因因素的努力。