FUNCTIONAL ASYMMETRY--COGNITIVE DEFICIENCIES

先前的研究表明，精神分裂症患者 在某些方面表现出明显更大程度的不对称性 形态特征（例如皮纹）比正常或 affectively disordered subjects. It has been assumed that this 不对称反映了与相关的“波动不对称” 许多不同基因座的纯合性水平很高。 对其他多基因疾病的研究表明，波动 不对称性可以用作多基因遗传的标志。 因此，观察结果表明，作为一个群体，精神分裂症患者 受试者表现出明显的波动不对称表明一种新的 检验有关该遗传基质的假设的方法 紊乱。 该提案概述了旨在检查 1) 的实验 理论上认知任务表现之间的关联 精神分裂症的脆弱性标记和程度波动 asymmetry in dermatoglyphic traits; 2) the relationship between 皮纹不对称和与正常模式的偏差 3）大脑偏侧化之间的关系 皮纹不对称和某些亚组策略 精神分裂症。

Previous research has demonstrated that schizophrenic subjects exhibit a significantly greater degree of asymmetry on certain morphological traits (e.g., dermatoglyphics) than normal or affectively disordered subjects. It has been assumed that this asymmetry reflects the "fluctuating asymmetry" associated with high levels of homozygosity at a number of different loci. Research on other polygenic disorders has shown that fluctuating asymmetry can be used as a marker of polygeneic inheritance. Therefore, the observation that, as a group, schizophrenic subjects show marked fluctuating asymmetry suggests a new method for testing hypotheses about the genetic substrate of this disorder. This proposal outlines experiments designed to examine 1) the association between performance on cognitive tasks theorized to be schizophrenic vulnerability markers and degree of fluctuating asymmetry in dermatoglyphic traits; 2) the relationship between dermatoglyphic asymmetry and deviations from normal patterns of cerebral lateralization 3) the relationship between dermatoglyphic asymmetry and certain subgrouping strategies for schizophrenia.