DEVELOPMENTAL INSTABILITY--ORIGINS AND EVOLUTION

发育不稳定——起源与演变

• 批准号: 3435435
• 负责人: THERESE A MARKOW
• 金额: $ 0.5万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-06-01 至 1994-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435435
• 关键词: biochemical evolution; developmental genetics; epidemiology; gene frequency; meeting /conference /symposium; population genetics; statistics /biometry; teratogens; travel

Developmental instability (DI), or the failure of an organism to develop according to its ontogenetic plan, has been receiving a great deal of attention. It may manifest itself in the form of minor physical anomalies (MAPs) or random deviations from anticipated bilateral symmetry (fluctuating asymmetry or FA). DI has been shown to result from genetic and/or environmental factors in man as well as experimental organisms. DI is often used to indicate prenatal insults or increased risk for various disorders. However, appropriate ways to measure DI, especially in the contexts of- genetic epidemiology and teratology, are still being explored. In addition, the basis for genetic vulnerability to DI (homozygosity vs coadaptation) is not understood. A conference/workshop to address these problems is proposed in this application. Researchers with expertise in genetics, statistics and developmental biology will convene to define issues in need of clarification, suggest empirical studies to address these issues and develop recommendations for standardized methods of measuring DI. The proceedings are to be published in a volume by Kluwer Academic Press.

发育不稳定(DI)，或生物体不能发育 根据其个体发育计划，已经收到了大量的 请注意。它可能会以次要的物理形式表现出来 偏离预期双边对称性的异常(地图)或随机偏差 (波动不对称或FA)。DI已被证明是由基因引起的 和/或环境因素对人类和实验生物体的影响。 Di通常用来表示产前的侮辱或增加 各种疾病。然而，测量DI的适当方法，尤其是 在遗传流行病学和畸形学的背景下，仍在 探索过了。此外，DI的遗传易感性的基础 (纯合性与共适应)尚不清楚。 建议召开一次会议/研讨会来解决这些问题。 申请。研究人员在遗传学、统计学和 发育生物学将召开会议，确定需要解决的问题 澄清，建议进行实证研究来解决这些问题，并 为测量DI的标准化方法制定建议。这个 会议记录将由克鲁沃学术出版社以卷的形式出版。