DEVELOPMENTAL INSTABILITY--ORIGINS AND EVOLUTION

发育不稳定性（DI），或生物体发育失败 根据它的个体发育计划， 关注 它可能会以轻微的身体不适的形式出现， 异常（MAP）或预期双侧对称性的随机偏差 （波动不对称或FA）。 DI已被证明是由遗传引起的 和/或人类以及实验生物体中的环境因素。 DI通常用于表示产前损伤或增加的风险， 各种疾病 然而，测量DI的适当方法，特别是 在遗传流行病学和畸形学的背景下， 探讨了 此外，遗传易受DI影响的基础 （纯合性与共适应性）还不清楚。 本文件提议召开一次会议/研讨会来解决这些问题 应用程序. 具有遗传学、统计学和 发育生物学将召开会议，以确定需要解决的问题， 澄清，建议进行实证研究，以解决这些问题， 制定测量DI的标准化方法的建议。 的 会议记录将由Kluwer Academic Press出版。

Developmental instability (DI), or the failure of an organism to develop according to its ontogenetic plan, has been receiving a great deal of attention. It may manifest itself in the form of minor physical anomalies (MAPs) or random deviations from anticipated bilateral symmetry (fluctuating asymmetry or FA). DI has been shown to result from genetic and/or environmental factors in man as well as experimental organisms. DI is often used to indicate prenatal insults or increased risk for various disorders. However, appropriate ways to measure DI, especially in the contexts of- genetic epidemiology and teratology, are still being explored. In addition, the basis for genetic vulnerability to DI (homozygosity vs coadaptation) is not understood. A conference/workshop to address these problems is proposed in this application. Researchers with expertise in genetics, statistics and developmental biology will convene to define issues in need of clarification, suggest empirical studies to address these issues and develop recommendations for standardized methods of measuring DI. The proceedings are to be published in a volume by Kluwer Academic Press.