ANTIDEPRESSANT DRUGS IN TREATMENT OF ANXIETY DISORDERS

该研究包括一个双盲，随机，安慰剂 丙咪嗪治疗广场恐怖症80例对照研究 没有明显的抑郁-烦躁， 同时鼓励和/或指示进入恐惧症 情况，以评估具体的抗恐慌程度， 药物的抗恐惧作用， 可能 各由20名受试者组成的治疗组包括 安慰剂和三种不同的体重调整丙咪嗪剂量 例如，在一个实施例中，0.5 1.5 mg/kg/天或3 mg/kg/天 在为期八周的时间内， 安慰剂阶段，以消除安慰剂应答者。 具体目标 研究的目的是描述和分层剂量反应 与中枢广场恐惧症症状的关系，即，恐慌， 恐惧症，回避行为，首先确定最佳 剂量/血浆浓度响应关系， 表明药物具体和可能不同的作用机制 对这些不同的症状维度采取行动。

The study consists of a double-blind, randomized, placebo controlled trial with imipramine in 80 agoraphobic patients without significant depression-dysphoria and in the absence of concurrent encouragement and/or instructions to enter phobic situations in order to assess the extent of specific antipanic and antiphobic effects of the drug with as little contamination as possible. Treatment groups each consisting of 20 subjects include placebo and three different weight-adjusted imipramine dosages e.g., 0.5 mg/kg per day, 1.5 mg/kg per day or 3 mg/kg per day over an eight week period preceded by a single-blind two-week placebo phase to eliminate placebo responders. The specific aim of the study is to delineate and stratify dose response relationships for the central agoraphobic symptoms i.e., panic, phobia, avoidance behavior to first determine the optimum dose/plasma concentration response relationships which would indicate specific and possibly differential mechanisms of drug action on these various symptom dimensions.