ANTIDEPRESSANT DRUGS IN TREATMENT OF ANXIETY DISORDERS

该研究由双盲、随机、安慰剂组成 丙咪嗪治疗80例广场恐怖症对照试验 没有明显的抑郁-焦虑症，在没有 同时鼓励和/或指示进入恐惧症 情况，以评估特定的反恐慌和 这种药物的抗恐惧性，污染小到 有可能。每个由20名受试者组成的治疗组包括 安慰剂和三种不同重量调整的丙咪嗪剂量 例如每天0.5毫克/公斤、每天1.5毫克/公斤或每天3毫克/公斤 在之前的八周时间里，单盲两周 安慰剂阶段，消除安慰剂应答者。具体目标 这项研究的目的是描绘和分层剂量反应 中枢广场恐惧症症状的关系，即恐慌， 恐惧症，回避行为要先确定最优 剂量/血浆浓度反应关系 指出药物的特定和可能的不同作用机制 对这些不同的症状维度采取行动。

The study consists of a double-blind, randomized, placebo controlled trial with imipramine in 80 agoraphobic patients without significant depression-dysphoria and in the absence of concurrent encouragement and/or instructions to enter phobic situations in order to assess the extent of specific antipanic and antiphobic effects of the drug with as little contamination as possible. Treatment groups each consisting of 20 subjects include placebo and three different weight-adjusted imipramine dosages e.g., 0.5 mg/kg per day, 1.5 mg/kg per day or 3 mg/kg per day over an eight week period preceded by a single-blind two-week placebo phase to eliminate placebo responders. The specific aim of the study is to delineate and stratify dose response relationships for the central agoraphobic symptoms i.e., panic, phobia, avoidance behavior to first determine the optimum dose/plasma concentration response relationships which would indicate specific and possibly differential mechanisms of drug action on these various symptom dimensions.