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Synthesis of Amides from Nitriles via Multifaceted Catalysis

多面催化从腈合成酰胺

基本信息

批准号：
EP/J003298/1
负责人：
Jason Camp
金额：
$ 12.71万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2012
资助国家：
英国
起止时间：
2012 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FJ003298%2F1
关键词：
Synthesis Amides Nitriles via Multifaceted

项目摘要

Humankind faces a number of challenges revolving around health, energy, agriculture and the environment. Chemical synthesis is at the heart of the research into these issues as it can deliver the complex compounds required to overcome these challenges. The synthesis of the complex molecules on which we all depend is increasingly a balance between cost and benefit. There is an urgent need to develop novel methods to access these compounds that maximises our resources whilst reducing the overall cost of the process. Finding clean and efficient methods for the formation of added-value compounds from simple low cost starting materials is one of the major challenges facing chemists and chemical engineers. One approach to overcome these challenges that is used extensively in all areas of contemporary synthesis is catalysis. A catalyst is a compound that lowers the energy required to effect a chemical reaction leading to more mild and efficient processes. To overcome some of the challenges associated with complex molecule formation, our research develops a clean, mild and efficient method for the formation of valuable compounds called amides from an underutilised chemical feedstock by using catalysis. Amides (RCONH2) are utilised extensively in the study of biological process as well as in the synthesis of pharmaceuticals, agrochemicals and polymers. Unfortunately, traditional methods for amide formation produce a significant amount of by-products and waste. Reducing the amount of waste produced during amide formation is the number one problem facing the pharmaceutical industry as recently highlighted at a roundtable discussion of leading scientists.Our research seeks to catalytically activate nitriles to avoid the use of wasteful reagents and lead to a more efficient synthesis of amides. Nitriles are a functional group that contain a carbon-nitrogen triple bond and are used for a variety of carbon-carbon and carbon-nitrogen bond forming reactions. These sorts of transformations are vital for the synthesis of the range of chemical, pharmaceutical, and raw materials on which our society depends. In addition to providing improved access to these important compounds, this method will ultimately benefit the economy, environment and the day-to-day quality of life of the general public by making important compounds readily available at decreased overall costs.

人类面临着围绕健康、能源、农业和环境的一系列挑战。化学合成是研究这些问题的核心，因为它可以提供克服这些挑战所需的复杂化合物。我们所依赖的复杂分子的合成越来越需要在成本和效益之间取得平衡。迫切需要开发新的方法来获得这些化合物，最大限度地利用我们的资源，同时降低整个过程的成本。从简单的低成本起始材料中寻找清洁有效的方法来形成附加值化合物是化学家和化学工程师面临的主要挑战之一。在当代合成的所有领域中广泛使用的克服这些挑战的一种方法是催化。催化剂是一种化合物，它可以降低化学反应所需的能量，从而产生更温和、更有效的过程。为了克服与复杂分子形成相关的一些挑战，我们的研究开发了一种清洁，温和和有效的方法，用于通过使用催化剂从未充分利用的化学原料中形成有价值的化合物，称为酰胺。酰胺（RCONH 2）广泛用于生物过程的研究以及药物，农用化学品和聚合物的合成。不幸的是，用于酰胺形成的传统方法产生显著量的副产物和废物。减少酰胺形成过程中产生的废物量是制药行业面临的首要问题，最近在一次由领先科学家参加的圆桌讨论会上强调了这一点。我们的研究旨在催化活化腈，以避免使用浪费的试剂，并提高酰胺的合成效率。腈是含有碳-氮三键的官能团，用于各种碳-碳和碳-氮键形成反应。这些类型的转化对于我们社会所依赖的化学、制药和原材料的合成至关重要。除了提供对这些重要化合物的改进的获取之外，该方法将通过以降低的总成本使重要化合物容易获得而最终有益于经济、环境和公众的日常生活质量。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Synthesis of 2,4-Disubstituted Imidazoles via Nucleophilic Catalysis

DOI：
10.1055/s-0039-1690832
发表时间：
2020-02
期刊：
Synlett
影响因子：
2
作者：
J. Camp;D. Shabalin;Jay J. Dunsford;Simbarashe Ngwerume;A. R. Saunders;Duncan M. Gill
通讯作者：
J. Camp;D. Shabalin;Jay J. Dunsford;Simbarashe Ngwerume;A. R. Saunders;Duncan M. Gill

Multifaceted catalysis approach to nitrile activation: direct synthesis of halogenated allyl amides from allylic alcohols.

腈活化的多方面催化方法：由烯丙醇直接合成卤化烯丙基酰胺。

DOI：
10.1039/c3ob41692e
发表时间：
2013
期刊：
Organic & biomolecular chemistry
影响因子：
3.2
作者：
Lester RP
通讯作者：
Lester RP

Platinum-catalysed synthesis of trichloroamidines

铂催化合成三氯脒

DOI：
10.1016/j.tetlet.2013.06.062
发表时间：
2013
期刊：
Tetrahedron Letters
影响因子：
1.8
作者：
Dunsford J
通讯作者：
Dunsford J

Dehydrative Cross-Coupling of 1-Phenylethanol Catalysed by Palladium Nanoparticles Formed in situ Under Acidic Conditions

DOI：
10.1055/s-0037-1610246
发表时间：
2018-08
期刊：
Synthesis
影响因子：
0
作者：
J. Camp;Thomas W. Bousfield;Jay J. Dunsford;James Adams;J. Britton;M. Fay;A. Angelis-Dimakis
通讯作者：
J. Camp;Thomas W. Bousfield;Jay J. Dunsford;James Adams;J. Britton;M. Fay;A. Angelis-Dimakis

ChemInform Abstract: Synthesis of Heterocycles via Gold Multifaceted Catalysis

ChemInform 摘要：通过金多面催化合成杂环