NIMH-CRB PSYCHOBIOLOGY DEPRESSION PROGRAM-BIO

NIMH-CRB 心理生物学抑郁项目-BIO

• 批准号: 3383913
• 负责人: MARTIN M KATZ
• 金额: $ 9.79万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3383913
• 关键词: antidepressants; anxiety; bipolar depression; catecholamines; disease /disorder classification; drug metabolism; human therapy evaluation; mental disorder chemotherapy; neurobiology; neurochemistry; neuroendocrine system; neurotransmitter metabolism; psychobiology; psychopharmacology

The major aim this sex-center collaborative study was to test hypotheses which implicate neurobiological mechanisms in the etiology and maintenance of the affective disorders. The collaborative approach was developed in order to provide a consortium of investigators having expertise in diverse disciplines to design and conduct the research. The study utilized uniform diagnostic criteria and behavioral methods, so as to assess the functioning of multiple biological systems in the same subjects. It provided for assessment during a baseline drug-free period and after four weeks of anti-depressant drug treatment. This collaborative effort makes it possible to test earlier and current hypotheses, and to examine interactions across and among biological systems and behavior. All data analysis for the initial phase of hypothesis testing has been essentially completed. This grant application represents a request for a final period of support during which the second phase of the testing of hypotheses which involve two or more biological systems and behavior, will be brought to a conclusion.

这个以性为中心的合作研究的主要目的是测试