COMPUTED TOMOGRAPHY STUDY OF SCHIZOPHRENIA

精神分裂症的治疗策略(TSS)研究为期五年 由NIMH赞助的合作研究涉及五个地点。540名患者 在知情同意的情况下，精神分裂症患者将被招募进入 在需要住院治疗的疾病发作期间学习。在此之后 稳定期，患者将随机分配到双盲组 标准剂量、小剂量或安慰剂剂量的氟奋乃静治疗 在两年内，每两周一次。症状加重和复发 将接受开放的盐酸氟奋乃静治疗，如果 需要的。患者及其家属也将被随机分配到 适用或支持性的家庭管理条件。其主要目的是 研究这些不同的治疗策略并观察它们之间的相互作用 药理和家庭管理条件。 精神分裂症的CT研究计划对TSS进行CT扫描 患者进入双盲期，使用新一代CT 扫描仪。匹配的医疗控制扫描将从 放射档案比较精神分裂症受试者和 有侧脑室扩大证据的医学对照，脑沟 小脑萎缩，第三脑室增大。这个 正在测试的假设是，精神分裂症患者有侧位 脑室扩大将显示区别对待的反应 不同治疗条件对精神分裂症患者的影响 无侧脑室扩大。患有精神分裂症的患者 侧脑室扩大预计有较差的发病前 功能水平，症状以阴性症状为标志，较差 心理社会功能和较高的抗精神病药物副作用发生率。

The Treatment Strategies in Schizophrenia (TSS) study is a five year collaborative study sponsored by NIMH involving five sites. 540 patients with schizophrenia will be recruited, with informed consent, to enter the study during an episode of illness requiring hospitalisation. Following a period of stabilisation, patients will be randomly assigned to double-blind treatment with standard dose, low dose or placebo dose of fluphenazine decanoate every two weeks for two years. Symptom exacerbation and relapses will be treated with open fluphenazine hydrochloride and hospitalisation if needed. The patient and their families will also be randomly assigned to applied or supportive family management conditions. The major aim is to study these different treatment strategies and to look at the interaction of the pharmacological and family management conditions. The Computer Tomographic Study of Schizophrenia study plans to CT scan TSS patients as they enter the double-blind phase, using late generation CT scanners. Matched medical control scans will be obtained from the Radiology files to compare the proportion of schizophrenic subjects and medical controls having evidence of lateral ventricular enlargement, sulcal and cerebellar atrophy, and enlargement of the third ventricle. The hypothesis being tested is that schizophrenic patients with lateral ventricular enlargement will show differential treatment response to the different treatment conditions compared to the schizophrenic patients without lateral ventricular enlargement. Schizophrenic patients with lateral ventricular enlargement are expected to have a poorer premorbid level of functioning, symptomatology marked by negative symptoms, poorer psychosocial functioning and a higher incidence of neuroleptic side-effects.