COMPUTED TOMOGRAPHY STUDY OF SCHIZOPHRENIA

精神分裂症治疗策略（TSS）研究是一项为期五年的 由NIMH赞助的合作研究，涉及五个地点。 540例患者 精神分裂症患者将被招募，在知情同意的情况下， 在需要住院治疗的疾病发作期间进行研究。 后 在稳定期，患者将被随机分配至双盲 用标准剂量、低剂量或安慰剂剂量的氟奋乃静治疗 每两周吃一次癸酸盐，持续两年。 症状加重和复发 将接受开放式盐酸氟奋乃静治疗并住院，如果 needed. 患者及其家属也将被随机分配到 适用或支持的家庭管理条件。 主要目的是 研究这些不同的治疗策略并观察相互作用 药理学和家庭管理条件。 精神分裂症的CT研究拟对TSS进行CT扫描 患者进入双盲期时，使用新一代CT 扫描仪 匹配的医学对照扫描将从 放射学文件比较精神分裂症受试者的比例， 有侧脑室扩大证据的医学对照，脑沟 小脑萎缩第三脑室扩大 的 正在测试的假设是， 心室扩大将显示出不同的治疗反应 与精神分裂症患者相比， 没有侧脑室扩大。 精神分裂症患者 侧脑室扩大的患者发病前 功能水平，以阴性症状为标志的泌尿学，较差 心理社会功能和更高的神经抑制剂副作用发生率。

The Treatment Strategies in Schizophrenia (TSS) study is a five year collaborative study sponsored by NIMH involving five sites. 540 patients with schizophrenia will be recruited, with informed consent, to enter the study during an episode of illness requiring hospitalisation. Following a period of stabilisation, patients will be randomly assigned to double-blind treatment with standard dose, low dose or placebo dose of fluphenazine decanoate every two weeks for two years. Symptom exacerbation and relapses will be treated with open fluphenazine hydrochloride and hospitalisation if needed. The patient and their families will also be randomly assigned to applied or supportive family management conditions. The major aim is to study these different treatment strategies and to look at the interaction of the pharmacological and family management conditions. The Computer Tomographic Study of Schizophrenia study plans to CT scan TSS patients as they enter the double-blind phase, using late generation CT scanners. Matched medical control scans will be obtained from the Radiology files to compare the proportion of schizophrenic subjects and medical controls having evidence of lateral ventricular enlargement, sulcal and cerebellar atrophy, and enlargement of the third ventricle. The hypothesis being tested is that schizophrenic patients with lateral ventricular enlargement will show differential treatment response to the different treatment conditions compared to the schizophrenic patients without lateral ventricular enlargement. Schizophrenic patients with lateral ventricular enlargement are expected to have a poorer premorbid level of functioning, symptomatology marked by negative symptoms, poorer psychosocial functioning and a higher incidence of neuroleptic side-effects.