New Porphycene Macrocycles for Applications in Two-Photon Absorption: Optimisation and Synthesis

用于双光子吸收应用的新型卟啉大环化合物：优化与合成

• 批准号: EP/J006602/1
• 负责人: Martin Paterson
• 金额: $ 60.1万
• 依托单位: Heriot-Watt University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ006602%2F1
• 关键词: New; Porphycene; Macrocycles; Applications; Two

This proposal combines advanced state-of-the-art response theoretical computation with efficient, modern synthesis of structurally variable dibenzoporphycenes, and non-linear laser spectroscopy to probe structural and electronic parameters in a class of molecules that show very promising two-photon absorption (TPA) behaviour. The use of TPA shows many advantages over conventional excitation techniques, however, applications of these techniques are still in their infancy. We will model, prepare and study a new class of promising compounds for potential use in the treatment of cancer via what is known as photodynamic therapy. Here, TPA has the potential overcome many issues in this field, for example exploiting the tissue transparency window. This proposal is thus timely as it brings together the three strands of research required to investigate this new class of compounds. Compounds within this promising subset of aromatic macrocycles with optimal TPA properties will be discovered computationally and then prepared by flexible, convergent synthetic routes. This proposal will thus bring together a multi-disciplinary team to study this important topic.

该提案结合了先进的最先进的响应理论计算与结构可变的二苯并卟啉的高效现代合成，以及非线性激光光谱学来探测一类分子的结构和电子参数，这些分子显示出非常有前途的双光子吸收（TPA）行为。TPA的使用显示出许多优于传统激励技术的优点，然而，这些技术的应用仍处于起步阶段。我们将建模，制备和研究一类新的有前途的化合物，用于通过所谓的光动力疗法治疗癌症的潜在用途。在这里，TPA具有克服该领域中的许多问题的潜力，例如利用组织透明度窗口。因此，这项建议是及时的，因为它汇集了研究这类新化合物所需的三个研究领域。具有最佳TPA性能的芳香族大环化合物将通过计算发现，然后通过灵活，收敛的合成路线制备。因此，这项建议将汇集一个多学科小组来研究这一重要专题。

项目成果

Crossed McMurry Coupling Reactions for Porphycenic Macrocycles: Non-Statistical Selectivity and Rationalisation.

• DOI: 10.1002/ejoc.201500221
• 发表时间: 2015-06
• 期刊: European journal of organic chemistry
• 影响因子: 2.8
• 作者: Cowie TY;Kennedy L;Żurek JM;Paterson MJ;Bebbington MW
• 通讯作者: Bebbington MW

Influence of electronic effects on one- and two-photon absorption in porphyrin isomers

电子效应对卟啉异构体单光子和双光子吸收的影响

• DOI: 10.1039/c3ra40790j
• 发表时间: 2013
• 期刊: RSC Advances
• 影响因子: 3.9
• 作者: Bergendahl L

Excited-State Dynamics of a Two-Photon-Activatable Ruthenium Prodrug.

• DOI: 10.1002/cphc.201501075
• 发表时间: 2016-01-18
• 期刊: Chemphyschem : a European journal of chemical physics and physical chemistry
• 作者: Greenough SE;Horbury MD;Smith NA;Sadler PJ;Paterson MJ;Stavros VG
• 通讯作者: Stavros VG

Two-photon absorption-molecular structure investigation using a porphycene chromophore with potential in photodynamic therapy.

• DOI: 10.1021/jp305063e
• 发表时间: 2012-09
• 期刊: The journal of physical chemistry. B
• 作者: L. Bergendahl;M. Paterson

Manipulating dynamics with chemical structure: probing vibrationally-enhanced tunnelling in photoexcited catechol.

• DOI: 10.1039/c3cp51108a
• 发表时间: 2013-04
• 期刊: Physical chemistry chemical physics : PCCP
• 作者: A. Chatterley;J. D. Young;D. Townsend;Justyna M. Żurek;M. Paterson;G. Roberts;V. Stavros