Epitranscriptomic regulation of learning and memory

学习和记忆的表观转录调控

• 批准号: DE170100112
• 负责人: Dr Jocelyn Widagdo
• 金额: $ 27.9万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100112
• 关键词: Epitranscriptomic; regulation; learning; memory

This project aims to investigate m6A, the most prevalent internal modification in eukaryotic messenger RNA, in the mammalian brain. The adult brain contains a high level of reversible m6A, suggesting that m6A regulates the neuronal transcriptome during synaptic plasticity, the cellular basis of learning and memory. This project will use epitranscriptomics to investigate the more than 100 modifications on RNA, many of which are not yet characterised. Through molecular and mouse behavioural assays, the expected outcomes are insights into the post-transcriptional regulation underlying learning and memory, essential for survival in a constantly changing environment.

该项目旨在研究哺乳动物大脑中真核生物信使RNA中最普遍的内部修饰m6A。成人大脑含有高水平的可逆m6 A，这表明m6 A在突触可塑性（学习和记忆的细胞基础）期间调节神经元转录组。该项目将使用epitranscriptomics来研究RNA上的100多种修饰，其中许多尚未被表征。通过分子和小鼠行为测定，预期结果是深入了解学习和记忆的转录后调节，这对在不断变化的环境中生存至关重要。