Novel role of RNA methylation in neuronal homeostasis

RNA甲基化在神经元稳态中的新作用

• 批准号: DP230102041
• 负责人: Dr Jocelyn Widagdo
• 金额: $ 33.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-11-09 至 2026-11-08
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230102041
• 关键词: Novel; role; RNA; methylation; neuronal

This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise high-throughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mechanistic insights into the molecular processes that control neuronal homeostatic responses. This will elucidate how neural plasticity and network stability are maintained, a process that is critical for our understanding of sensory processing, learning and memory throughout life.

该提案旨在了解神经元稳态反应中发生的 RNA 信号传导。神经元稳态对于正常大脑功能的关键作用在整个神经系统中得到了证明。然而，确切的潜在机制仍不清楚。拟议的研究将利用高通量测序方法与生化、分子和细胞生物学测定相结合，为控制神经元稳态反应的分子过程提供机制见解。这将阐明如何维持神经可塑性和网络稳定性，这一过程对于我们理解一生中的感觉处理、学习和记忆至关重要。