NEUROPATHOLOGY OF DEMENTIA IN ELDERLY SCHIZOPHRENIC

老年精神分裂症痴呆的神经病理学

• 批准号: 3386241
• 负责人: MICHAEL DAVIDSON
• 金额: $ 33.71万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3386241
• 关键词: Alzheimer's disease; aging; cognition; histology; human old age (65+); human subject; longitudinal human study; mental disorder diagnosis; nervous system disorder; postmortem; schizophrenia

Cognitive impairments that clinically resemble dementia are frequently observed in elderly schizophrenic patients. The study proposed in this application will investigate if the "dementia" observed in these elderly schizophrenic patients share the same neurohistological substrates as in known dementing illnesses like Senile Dementia of the Alzheimer's Type or Multi Infarct Dementia. Such a finding would indicate that observed cognitive deficits may be independent of the schizophrenia and reflect the concurrent presence of another dementing illness. Alternatively, brains derived from cognitively and functionally impaired elderly schizophrenic patients will not meet neuropathological criteria for known dementing illnesses. Such a finding would strongly suggest that elderly schizophrenic patients with cognitive dysfunction are affected by a clinical condition which resembles other recognizable dementing illnesses (Senile Dementia of Alzheimer's Type, Multi Infarct Dementia), but without the corresponding neuropathological correlates characteristic of these dementias. This potential outcome would further suggest that the severe cognitive and functional impairment observed in some elderly patients is another aspect of the schizophrenic illness, and not a concomitant known dementing illness. In order to achieve these aims, detailed cognitive and functional assessments will be conducted antemortem in patients who are older than 65 years and who meet DSMIII-R criteria for schizophrenia. These patients will be followed until death at which time the brain will be expeditiously removed and neurohistologically assessed. This study will be conducted as a collaboration between the Department of Psychiatry and Neuropathology at Mount Sinai School of Medicine and the New York State Pilgrim Psychiatric Center.

临床上类似痴呆的认知障碍经常 在老年精神分裂症患者中观察到。 这项研究提出了 应用将调查这些老年人中是否观察到“痴呆症” 精神分裂症患者的神经组织学底物与 已知的痴呆疾病，例如老年痴呆症的老年痴呆症或 多梗塞痴呆症。 这样的发现表明观察到 认知缺陷可能独立于精神分裂症，反映 同时存在另一种痴呆疾病。 或者，大脑 源自认知和功能障碍的老年精神分裂症 患者将不符合已知痴呆的神经病理学标准 疾病。 这样的发现强烈表明老年人 认知功能障碍的精神分裂症患者受A的影响 类似于其他可识别性痴呆疾病的临床状况 （阿尔茨海默氏症类型的老年痴呆症，多梗塞痴呆），但没有 相应的神经病理学相关性 痴呆症。 这种潜在的结果将进一步表明严重 在一些老年患者中观察到的认知和功能障碍是 精神分裂症的另一个方面，而不是伴随的 痴呆疾病。 为了实现这些目标，详细的认知和 功能评估将在患者的患者中进行。 超过65岁，符合精神分裂症的DSMIII-R标准。 这些患者将被遵循直到死亡，此时大脑将是 迅速删除并通过神经组织学评估。 这项研究将是 作为精神病学系与 西奈山医学院和纽约州的神经病理学 朝圣者精神病中心。