Synthetic Anionophores with Therapeutic Potential - a Coordinated Two-Centre Approach

具有治疗潜力的合成阴离子载体——协调的两中心方法

• 批准号: EP/J009687/1
• 负责人: Philip Alan Gale
• 金额: $ 40.46万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ009687%2F1
• 关键词: Synthetic; Anionophores; Therapeutic; Potential; Coordinated

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，所有资助研究的摘要都不能在GTR中找到。这通常是因为在提交提案时并不需要摘要，但可能是因为它包含了个人详细信息等敏感信息。

项目成果

Fluorescent transmembrane anion transporters: shedding light on anionophoric activity in cells.

• DOI: 10.1039/c6sc01643j
• 发表时间: 2016-08-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Berry SN;Soto-Cerrato V;Howe ENW;Clarke HJ;Mistry I;Tavassoli A;Chang YT;Pérez-Tomás R;Gale PA
• 通讯作者: Gale PA

High-affinity anion binding by steroidal squaramide receptors.

类固醇方酰胺受体的高亲和力阴离子结合。

• DOI: 10.1002/anie.201411805
• 发表时间: 2015-04-07
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Edwards, Sophie J.;Valkenier, Hennie;Busschaert, Nathalie;Gale, Philip A.;Davis, Anthony P.
• 通讯作者: Davis, Anthony P.

A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations.

• DOI: 10.1038/nchem.2706
• 发表时间: 2017-07
• 期刊: Nature chemistry
• 影响因子: 21.8
• 作者: Busschaert N;Park SH;Baek KH;Choi YP;Park J;Howe ENW;Hiscock JR;Karagiannidis LE;Marques I;Félix V;Namkung W;Sessler JL;Gale PA;Shin I
• 通讯作者: Shin I

Thiosquaramides: pH switchable anion transporters.

• DOI: 10.1039/c4sc01629g
• 发表时间: 2014-09-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Busschaert N;Elmes RB;Czech DD;Wu X;Kirby IL;Peck EM;Hendzel KD;Shaw SK;Chan B;Smith BD;Jolliffe KA;Gale PA
• 通讯作者: Gale PA