MECHANICS OF THE ORGAN OF CORTI

我们的目标是理解机械的作用 (流体-弹性-粘弹性)将声音转化为 受体细胞刺激。这将是数学的延续 适当采用波的渐近技术的研究 分析。这项工作的基础是只使用生理学的 数学模型中的参数。最近的结果是(1)频率 可以仅根据宽度来解释沿耳蜗处的定位， 基底膜梳状带厚度和纤维密度(PMP)； (2)BMP的反应受耳蜗曲率、张开度的影响不大。 和一个Scala的部分引流，以及Corti器官的细节 僵硬；(3)马蹄蝠中发现的调谐耳蜗谐振器， 导致频率处的BM幅度急剧下降，而不是峰值 以及(4)直流电必须是耳蜗的一个重要特征 功能。蝙蝠耳蜗的结果表明，大部分电流 想法是不正确的。 拟议工作的具体成就包括： (1)将“大有限元”方法从二维推广到三维 人工耳蜗模型。这是一种结合了计算 具有直接数值能力的“WKB”方法的效率 处理不连续的方法。具体地说， 将确定马蹄形蝙蝠的分区响应。 (2)建立器官的真实非耦合细观力学模型 科尔蒂和脑沟的液体流动。一种新的定量计算方法 将进行流体流动的交替和流动分量， 无论有没有“主动”进程。蝙蝠和鳄鱼蜥蜴 我们将详细研究耳蜗骨。理解人类的听觉和 如果围绕着这些专门化的问题，障碍将会进一步发展 耳蜗病是可以解决的。

The objective is to understand the role of the mechanical (fluid-elastic-visco-elastic) activity in the transformation of sound into receptor cell stimulation. This will be a continuation of mathematical studies involving appropriate adoptation of asymptotic techniques of wave analysis. Fundamental to this work is the use of only physiological parameters in the mathematical models. Recent results are (1) frequency localization along the cochlea can be explained in terms of only the width, thickness and fiber density of the basilar membrane pectinate zone (PMP); (2) the response of BMP is little affected by cochlear curvature, opening and partial draining of one scala, and by details of the organ of Corti stiffness; (3) a tuned cochlear resonator, found in the horseshoe bat, causes a sharp drop, rather than a peak, in BM amplitude at the frequency of tuning; and (4) DC streaming must be an important feature of cochlear function. The bat cochlea results indicate that much of the current thought is incorrect. Specific accomplishments in the proposed work are to include: (1) Extension of the "large finite element" approach from 2-D to 3-D cochlear models. This is an approach which combines the computational efficiency of the 'WKB' method with the capability of direct numerical methods for handling discontinuities. Specifically, the details of the horseshoe bat partition response will be determined. (2) Development of a realistic uncoupled micromechanical model of the organ of Corti and sulcus fluid flow. A quantitative calculation for the alternating and streaming components of fluid flow will be carried out, both with and without "active" processes. The bat and alligator lizard cochleas will be examined in detail. Understanding human hearing and the disorders will be advanced if the questions surrounding these specialized cochleas can be resolved.