RESEARCH CENTER ON THE PSYCHOBIOLOGY OF ETHNICITY

种族心理生物学研究中心

• 批准号: 3387011
• 负责人: KEH-MING LIN
• 金额: $ 91.87万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1996-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3387011
• 关键词: human subject; pharmacogenetics; psychopharmacology; racial /ethnic difference

Despite an increased awareness of the relevance of psychobiology and psychopharmacology to the care of ethnic minority mental health patients, and the growing recognition of substantial ethnic and cultural diversity in psychobiological processes and responses, relatively few controlled investigations have been conducted to examine these issues. Results of such studies are important not only for the clinical care of patients with divergent ethnic backgrounds, but also have significant basic science implications. In order to continue addressing these important clinical and theoretical issues in a systematic manner, this application seeks continued support for the Research Center on the Psychobiology of Ethnicity. Building on the solid foundation of the infrastructure, research models, and collaborative networks that have been established, the Center will continue to foster and promote research on issues relevant to the interface between ethnicity and psychobiology. Innovative research designs and state-of-the-art methodologies including those derived from pharmacogenetics, molecular biology, brain imaging and chronobiology will be utilized to further delineate mechanisms underlying ethnic differences (and similarities) in psychotropic response, to examine the psychobiologic and nosologic status of "culturally specific syndromes" and their relationship to existing DSM-III-R and DSM-IV diagnoses, and to explore other psychobiologic and psychopharmacologic issues in the context of ethnicity and culture. During this funding cycle, six Center-initiated projects will be implemented. These include: (1) Mechanisms of Ethnic Difference in Psychotropic Responses; (2) Ethnicity, Brain Imaging and Antidepressant Response; (3) Psychiatric Diagnosis and Biological Markers in Patients with Neurasthenia, Chronic Fatigue Syndrome and Depression; (4) Ethnicity and Tardive Dyskinesia; (5) Whole Blood Serotonin in Mental Retardation: Ethnic Influences; and, (6) The Effect of Caffeine on Cerebral Perfusion in African-Americans and Caucasians. In addition, a number of explorative projects will be developed throughout the duration of the grant. The activities of the Center, with its primary focus on psychobiologic issues, will complement other research on ethnic minority groups that are predominately psychosocial in nature, and help to ensure that our efforts in understanding issues confronting the rapidly increasing ethnic minority populations are comprehensive and encompass the entirety of the biopsychosocial model.

尽管人们越来越意识到心理生物学和 精神药理学对少数民族精神健康患者的护理， 以及人们日益认识到种族和文化的多样性 在心理生物学的过程和反应中， 当局已就这些问题进行调查。结果 这些研究不仅对患有糖尿病的患者的临床护理很重要， 不同的种族背景，但也有重要的基础科学 影响为了继续解决这些重要的临床和 理论问题，本申请寻求 继续支持心理生物学研究中心， 种族。 建立在基础设施、研究模型、 和已建立的合作网络，该中心将 继续促进和推动对与《公约》有关的问题的研究， 种族和心理生物学之间的联系 创新研究 设计和最先进的方法，包括那些来自 药物遗传学、分子生物学、脑成像和时间生物学将 用于进一步阐明种族差异的机制 (and相似之处）的精神反应，以检查心理生物学 和“文化特异性综合征”的疾病分类地位及其 与现有DSM-III-R和DSM-IV诊断的关系，并探讨 其他精神生物学和精神药理学问题， 种族和文化。 在本供资周期内，将开展六个中心发起的项目， 切实贯彻 这些问题包括：（1）种族差异的机制 精神药物反应;（2）种族、脑成像和抗抑郁药 缓解;（3）患者的精神病诊断和生物标志物 神经衰弱、慢性疲劳综合征和抑郁症;（4）种族 和迟发性运动障碍;（5）精神发育迟滞中的全血5-羟色胺： 种族影响;（6）咖啡因对脑灌注的影响 在非裔美国人和高加索人中。 此外，一些探索性 在资助期内，有关计划将会持续发展。 该中心的活动，其主要重点是心理生物学 问题，将补充其他研究少数民族群体， 主要是心理社会的性质，并有助于确保我们的努力， 在理解迅速增加的少数民族所面临的问题时， 人口是全面的，包括整个 生物心理社会模式