RESEARCH CENTER ON THE PSYCHOBIOLOGY OF ETHNICITY

描述（改编自申请人摘要）：该中心是 成立于1990年。其主要使命是弥合 生物学和社会文化研究工作， 建立一个更全面的生物、心理、社会和文化综合体， 精神病学研究和实践的方法。这份更新申请 寻求五年的支持，以继续和扩大该中心的研究 施政纲要的演讲建立在其基础设施的坚实基础上， 在过去五年中开发的研究工具，该中心计划 将先进的研究方法应用于临床和社区 设置，同时评估生物， 精神病发病率、疾病分类学和 治疗反应，并检查这些因素如何相互作用 彼此之间。还将介绍保健服务方法， 允许使用来自现有药物处方的数据 监控系统 本建议书所包括的研究项目包括五项研究 研究领域包括：（1） 最近开发的药物遗传学探针具有多种族/多 患有不同精神疾病的文化患者;（2） 使用磁共振波谱测量大脑中的锂浓度 与锂反应的种族差异有关;（3） 抑郁症的生物心理社会评估，包括横断面和 纵向，在一个多民族的精神卫生保健设置;（4）长期- 社区华裔儿童长期纵向随访研究 ICD-10定义的神经衰弱患者;（5）使用大剂量 药物处方的次要数据集，以研究种族 与其他临床和社会人口统计学变量相互作用， 药物处方的模式。 这种生物医学和社会文化传统的更充分融合将 有助于确保精神病学研究的进展 适当和有效地应用于各种患者 社会文化和种族背景。与此同时， 跨文化的观察和测试将大大有助于 精神病学理论的验证和进一步发展， 实践

DESCRIPTION (Adapted from Applicant's Abstract): The Center was established in 1990. Its primary mission is to bridge the gap between biological and sociocultural research efforts and to contribute towards the establishment of a more fully integrated bio-psycho-socio-cultural approach to psychiatric research and practice. This renewal application seeks five years of support to continue and expand the Center's research agenda. Building upon the solid foundation of its infrastructure and research tools developed over the past five years, the Center plans to apply advanced research methodologies into clinical and community settings, to concurrently assess the influence of biological, psychosocial and cultural factors in psychiatric morbidity, nosology and treatment responses, and to examine how these factors might interact with one another. Also introduced will be health services methodology to allow the use of data derived from an existing medication prescription monitoring system. The research projects included in this proposal include five research areas examining the following issues: (1) the clinical utility of recently developed pharmacogenetic probes with multi-ethnic/multi- cultural patients suffering from different psychiatric conditions; (2) the use of MR spectroscopy to measure lithium concentration in the brain in relation to ethnic differences in response to lithium; (3) biopsychosocial assessment of major depression, both cross-sectional and longitudinal, in a multi-ethnic mental health care setting; (4) long- term longitudinal follow-up of a community sample of Chinese-American patients with ICD-10 defined neurasthenia; and (5) the use of a large secondary data set of medication prescriptions to study how ethnicity interacts with other clinical and sociodemographic variables in affecting the patterns of medication prescription. This fuller integration of biomedical and sociocultural traditions will help to ensure that advances in psychiatric research will be appropriately and effectively applied to patients from diverse sociocultural and ethnic backgrounds. At the same time, cross-ethnic and cross-cultural observations and testing will contribute significantly to the validation and further development of psychiatric theories and practices.