BRAIN DEVELOPMENT IN EXPERIMENTAL EPILEPSY

我们将研究长时间或反复发作癫痫引起的代谢变化。 新生兔和猴子的癫痫发作。重点将放在 持续癫痫发作会消耗新生灵长类动物的大脑葡萄糖，以及葡萄糖是否 然后，浓度成为糖酵解的速度限制。的影响 提高血糖浓度对代谢影响的标记研究 2-脱氧葡萄糖、脑损伤和存活率将被调查。这一机制 对大脑葡萄糖耗竭的影响将得到广泛的研究。我们还将继续我们的 癫痫发作抑制大脑机制的研究进展 新生儿体内的蛋白质合成。这将使用体内和体内的组合 体外方法，特别强调使用一些 来自网状结构的成分和来自大脑的其他成分。总体目标是 更好地了解癫痫发作对发育的影响 大脑。

We will study the metabolic changes induced by prolonged or repetitive epileptic seizures in newborn rabbits and monkeys. The emphasis will be on whether sustained seizures deplete brain glucose in newborn primates and whether glucose concentrations then become rate limiting for glycolysis. The effect of increasing blood glucose concentration on metabolism as studied by labelled 2-deoxyglucose, brain damage and survival will be investigated. The mechanism of brain glucose depletion will be studied extensively. We will also pursue our investigations of the mechanism by which epileptic seizures inhibit brain protein synthesis in the neonate. This will use a combination of in vivo and in vitro methods, with particular emphasis on cell-free systems using some component from reticulosites and others from brain. The overall goal is to provide a better understanding of the effect of seizures on the developing brain.