ANALYSIS OF THE RECURRENT RENSHAW CIRCUIT

这项建议涉及到组织和职能 脊髓复发性抑制的意义。这一点的重点是 建议是基于这样一个假设，即脊髓复发性抑制 使运动神经元放电失去同步性，这是由于 共同的突触驱动。这一假设将通过比较得到证实 运动神经元同步化的发生率和幅度 复发性闭塞前后的运动功能 给予胆碱能拮抗剂的抑制。推进器 刺激中脑将引起活动。 运动区，将检测到运动神经元同步 并使用矫正后的神经图的平均值进行量化。在……里面 加法。不同肌肉之间的同步模式 将组间比较复发抑制的分布情况 到他们的运动核团。将执行其他项目以 研究重复抑制在配对之间的分布 作为它们之间距离的函数的运动神经元 以获得对地震地点、震级和时间进程的估计 经常性抑制性突触后电位的电导。 这些项目的执行将确定 单个运动神经元对其他神经元的经常性抑制 运动神经元池中的运动神经元，并确定潜在的 反复抑制的强度。这些研究将被执行 使用细胞内记录技术。要确定 不同水平运动神经元的功能后果 同步，我们将检查同步的效果 关于力在等轴测和荷载移动过程中的发展 由一小部分运动人群的活动产生的收缩 单位。最后，反复抑制对脑电活动的影响。 放电，运动神经元种群的特征将是 在模拟中进行了检验。这些模拟的目的是为了 确定运动神经元池性能的敏感性 反复抑制的强度和分布的变化 以及不同来源的中枢兴奋性驱动。这些项目 这一建议将有助于理解中央 神经系统和神经肌肉疾病会导致震颤和 相关的运动障碍。

This proposal is concerned with the organization and functional significance of spinal recurrent inhibition. The emphasis in this proposal is on the by hypothesis that spinal recurrent inhibition acts to desynchronize motoneuron discharge which occurs due to common synaptic drive. This hypothesis will be rested by comparing the incidence and magnitude of motoneuron synchronization during locomotor activity before and after blockage of recurrent inhibition by administration of cholinergic antagonists. Locomotor activity will be evoked by stimulation of the mesencephalic locomotor region, and motoneuron synchronization will be detected and quantified using averages of rectified neurograms. In addition. Patterns of synchronization between different muscle groups will be compared to the distribution of recurrent inhibition to their motor nuclei. Other projects will be performed to investigate the distribution of recurrent inhibition between pairs of motoneurons as a function of the distance separating them and to obtain estimates of the location, magnitude and time course of the conductance of recurrent inhibitory postsynaptic potentials. These projects will be performed to determine the extent of recurrent inhibition from individual motoneurons to other motoneurons in a motoneuron pool, and to determine the potential strength of recurrent inhibition. These studies will be performed using intracellular recording techniques. To determine the functional consequences of varying levels of motoneuron synchronization, the effects of synchronization will be examined on the development of force during isometric and load-moving contractions produced by activity of a small population of motor units. Finally, the effect of recurrent inhibition on the discharge, characteristics of a population of motoneurons will be examined in simulations. The intent of these simulations is to determine the sensitivity of the performance of a motoneuron pool to changes in the strength and distribution of recurrent inhibition and to different sources of central excitatory drive. The projects in this proposal will contribute to understanding of central nervous system and neuromuscular diseases producing tremor and associated motor disorders.