RECURRENT RENSHAW CIRCUIT

伦肖循环电路

• 批准号: 6330423
• 负责人: THOMAS M HAMM
• 金额: $ 22.91万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6330423
• 关键词: cats; chordate locomotion; dendrites; electrical potential; electrophysiology; interneurons; motor neurons; neural information processing; neural inhibition; neuroanatomy; neuromuscular function; psychomotor function; single cell analysis; spinal cord injury; synapses

DESCRIPTION: (Applicant's abstract) The overall goal of this proposal is to determine the relation between the organization of centrally generated locomotor commands and known patterns of recurrent inhibition, and to investigate two sets of mechanisms that may determine the effect of this inhibition on motoneuron pools during locomotor and postural activity. Recent work from this laboratory suggests that: 1) the Renshaw cells which inhibit synergistic motor nuclei may form a network of interneurons linked by mutual inhibition; 2) the recurrent inhibition produced by Renshaw cells may affect the activity of motoneurons through synaptic interactions in the dendritic trees of motoneurons; and 3) the distribution of Renshaw inhibition is correlated with the distribution of locomotor commands to motor nuclei that innervate proximal limb muscles. Studies have been planned for this proposal to address three aims related to these observations. The first specific aim is to test the hypothesis that Renshaw cells activated by synergist groups of motoneurons are mutually inhibitory. If this hypothesis is confirmed, the strength and distribution of this mutual inhibition will be determined. The second specific aim is to determine the location of synaptic and intrinsic currents within the dendritic arbors of motoneurons. In these studies, interactions between Renshaw inhibition and several synaptic and intrinsic currents in motoneurons will be examined. The third specific aim is to compare the patterns of synaptic potentials to different functional groups of motoneurons during locomotor activity. These studies will address several issues concerning the central organization of locomotion, its relation to the organization of recurrent inhibition, and ability of correlation methods to assess the organization of spinal locomotor commands. Renshaw inhibition is associated with most motoneuron pools of limb muscles, and its regulation is compromised by spinal injury and upper motoneuron disease. The proposed studies will provide information on the control of the activity in motoneuron pools by Renshaw inhibition and the implications of disruption by disease or injury of control of this spinal system.

描述：（申请人的摘要）该提案的总体目标是 确定集中生成的组织之间的关系 运动命令和已知的反复抑制模式，以及 研究可能决定这种效果的两组机制 在运动和姿势活动期间对运动神经元池的抑制。 该实验室最近的工作表明：1) Renshaw 细胞 抑制协同运动核可能形成连接的中间神经元网络 通过相互抑制； 2) Renshaw细胞产生的反复抑制 可能通过突触相互作用影响运动神经元的活动 运动神经元的树突树； 3）Renshaw 分布 抑制与运动命令的分布相关 支配近端肢体肌肉的运动核。 研究已 该提案计划解决与这些相关的三个目标 观察。 第一个具体目标是检验伦肖的假设 由运动神经元协同组激活的细胞是相互抑制的。 如果这个假设得到证实，这个强度和分布 将确定相互抑制。 第二个具体目标是 确定突触和内在电流的位置 运动神经元的树突状乔木。 在这些研究中，之间的相互作用 伦肖抑制以及几种突触和内在电流 将检查运动神经元。 第三个具体目标是比较 不同功能组的突触电位模式 运动活动期间的运动神经元。 这些研究将解决几个问题 有关运动的中央组织及其关系的问题 反复抑制的组织和相关方法的能力 评估脊髓运动命令的组织。 伦肖抑制 与肢体肌肉的大多数运动神经元池相关，其调节 受到脊髓损伤和上运动神经元疾病的损害。 拟议的 研究将提供有关控制活动的信息 Renshaw 抑制对运动神经元池的影响以及破坏的影响 该脊柱系统的控制疾病或损伤。