PREFRONTAL CORTEX AND TEMPORAL INFORMATION PROCESSING

在目前的赠款建议的主要目的将是测试第一 动物和人类之间是否存在着 前额叶皮层介导记忆功能和第二次确定 前额叶皮层的特定亚区是否差异性地介导 特殊记忆功能。 有人提出，人类的基本缺陷，前额叶 皮层损伤是a）不能按时间顺序排列顺序 B）编码自我中心的困难 空间信息，也就是说，他们不能记住的反应， 取决于对一个人在空间中的身体方位的准确评估，以及c） 在适当处理情感信息方面的障碍， 情绪反应和表达的显著变化。 先前的研究表明，大鼠的前额叶皮层也 中介信息的时间结构以及自我中心 定位和影响，这表明动物之间的对应关系， 人类 为了进一步阐述各机构的作用， 前额叶皮层的子区域在处理时间信息， 已经在大鼠中开发了行为模型，其中可以测量a）a 用于空间位置列表的时间存储器LaA函数，B）用于 时间配置，c）单个刺激持续时间的记忆，或 特定刺激发生之间的持续时间，d）对 使用用于响应任务的记忆的自我中心定位，以及e）记忆 用记忆强化任务的强度来计算情感。 我建议使用这种动物模型作为继续研究的手段。 前额叶皮层在颞叶调节中的作用 排序、自我中心定位和情感信息。 人们希望 从这些研究中收集的信息将提供一种理解， 额叶综合征的合理治疗干预 可以被开发。

In the present grant proposal the major purpose will be to test first whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function and second to determine whether specific subregions of the prefrontal cortex differentially mediate specific memory functions. It has been proposed that the basic deficits in humans with prefrontal cortex damage are a) the inability to chronologically order sequential information on a short-term basis, b) a difficulty in coding egocentric spatial information, i,e,, they are not able to remember responses which depend upon accurate assessment of one's body orientation in space, and c) an impairment in appropriate processing of affect information as indicated by marked changes in emotional responsiveness and expression. Previous research has suggested that the prefrontal cortex in rats also mediates temporal structuring of information as well as egocentric localization and affect, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the various subregions of the prefrontal cortex in processing temporal information, a behavioral model has been developed in rats in which one can measure a) a temporal memory LaA function for a list of spatial locations, b) memory for temporal configurations, c) memory for duration of a single stimulus or duration of time between the occurrence of specific stimuli, d) memory for egocentric localization using a memory for a response task and e) memory for affect using a memory for magnitude of reinforcement task. I propose to use this animal model as a means of continuing the investigation of the role of the prefrontal cortex in mediating temporal ordering, egocentric localization and affect information. It is hoped that the information gleaned from these studies will provide an understanding of the frontal lobe syndrome such that a rational therapeutic intervention can be developed.