PREFRONTAL CORTEX AND TEMPORAL INFORMATION PROCESSING

在目前的提案中，主要目的将是测试 在动物和人类之间有一种对应的术语 前额叶皮质对记忆功能的调节作用。一直以来 提出人类前额叶皮质的基本缺陷 损害是无法在短期内订购信息 时态基础。这是基于临床观察和 认知测验的缺陷，在这些测验中，预期函数处理 与记忆的相对新近性被测量。 先前的研究表明，大鼠的前额叶皮质 调解信息的时间结构，暗示 动物与人类之间的通信。为了 进一步阐述前额叶皮质在大脑中的作用 处理时间信息，暗示一种对应 在动物和人类之间。为了进一步阐述 前额叶皮质在处理时间信息中的作用， 已经在大鼠身上建立了一种行为模型，在这种模型中，人们可以 测量a)用于特定产品列表的订单信息的存储器 视觉提示，b)存储特定产品列表的订单信息 电机响应，c)频率记忆，d)利用 记忆列表中的回溯性和前瞻性代码 空间位置。 有人建议使用这种动物模型作为一种继续 前额叶皮质在中枢调节中的作用研究 信息的时间顺序。第一个目标是确定 大鼠内侧前额叶皮质是否参与 特定视觉提示的时间(顺序)信息以及 特定的运动反应。第二个目标是确定 大鼠内侧前额叶皮质是否调节记忆 对于频率。第三个目标是确定内侧的 前额叶皮质参与了回顾和前瞻性研究 对顺序信息进行编码。第四个目标是确定 内侧前额叶皮质功能的独特性 研究眼眶-岛叶前额叶皮质的作用， 背外侧额叶皮质和顶叶皮质在调节中的作用 时间信息。 希望从这些研究中收集的信息将 提供对额叶综合征的了解，以便 合理的治疗干预是可以建立的。

In the present proposal, the major purpose will be to test whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function. It has been proposed that the basic deficit in humans with prefrontal cortex damage is the inability to order information on a short-term temporal basis. This is based on both clinical observations and deficits on cognitive tests in which prospective functions dealing with memory for relative recency are measured. Previous research has suggested that the prefrontal cortex in rats mediates temporal structuring of information, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the prefrontal cortex in processing temporal information, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the prefrontal cortex in processing temporal information, a behavioral model has been developed in rats in which one can measure a) memory for order information for a list of specific visual cues, b) memory for order information for a list of specific motor responses, c) memory for frequency, d) utilization of retrospective and prospective codes in remembering lists of spatial locations. It is proposed to use this animal model as a means of continuing the investigation of the role of prefrontal cortex in mediating temporal ordering of information. The first aim is to determine whether the medial prefrontal cortex in the rat mediates temporal (order) information for specific visual cues as well as for specific motor responses. The second aim is to determine whether the medial prefrontal cortex in the rat mediates memory for frequency. The third aim is to determine whether the medial prefrontal cortex is involved with retrospective and prospective coding of sequential information. The fourth aim is to determine possible uniqueness of function of the medial prefrontal cortex by examining the role of the orbito-insular prefrontal cortex, dorsolateral frontal cortex and parietal cortex in mediating temporal information. It is hoped that the information gleaned from these studies will provide an understanding of the frontal lobe syndrome such that a rational therapeutic intervention can be established.