PREFRONTAL CORTEX AND TEMPORAL INFORMATION PROCESSING

在本建议中，主要目的是测试是否 动物和人类之间有一种对应关系， 前额叶皮层对记忆功能的调节作用。 已经 提出人类前额皮质的基本缺陷 损害是无法短期订购信息 时间基础 这是基于临床观察和 在认知测试中，前瞻性功能处理 与记忆的相对近度进行测量。 先前的研究表明，大鼠的前额叶皮层 介导信息的时间结构，这表明 动物和人类之间的联系。 为了 进一步阐述前额叶皮层在 处理时间信息， 动物和人类之间的关系。 为了进一步阐述 前额叶皮层在处理时间信息中的作用， 已经在老鼠身上建立了一个行为模型， 措施a）存储特定的 视觉提示，B）用于特定的 运动反应，c）频率记忆，d）利用 回顾性和前瞻性代码在记忆列表中的作用 空间位置。 建议使用该动物模型作为继续研究的手段。 前额叶皮层在脑电介导中的作用 信息的时间顺序。 第一个目标是确定 大鼠的内侧前额叶皮层是否介导了 时间（顺序）信息的具体视觉线索，以及 特定的运动反应。 第二个目标是确定 大鼠的内侧前额叶皮层是否介导记忆 频率。 第三个目的是确定是否内侧 前额叶皮层参与了回顾性和前瞻性的 顺序信息的编码。 第四个目标是确定 内侧前额叶皮层功能的独特性 检查眶岛前额叶皮层的作用， 背外侧额叶皮层和顶叶皮层介导 时间信息 希望从这些研究中收集到的信息 提供对额叶综合征的理解， 可以建立合理的治疗干预。

In the present proposal, the major purpose will be to test whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function. It has been proposed that the basic deficit in humans with prefrontal cortex damage is the inability to order information on a short-term temporal basis. This is based on both clinical observations and deficits on cognitive tests in which prospective functions dealing with memory for relative recency are measured. Previous research has suggested that the prefrontal cortex in rats mediates temporal structuring of information, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the prefrontal cortex in processing temporal information, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the prefrontal cortex in processing temporal information, a behavioral model has been developed in rats in which one can measure a) memory for order information for a list of specific visual cues, b) memory for order information for a list of specific motor responses, c) memory for frequency, d) utilization of retrospective and prospective codes in remembering lists of spatial locations. It is proposed to use this animal model as a means of continuing the investigation of the role of prefrontal cortex in mediating temporal ordering of information. The first aim is to determine whether the medial prefrontal cortex in the rat mediates temporal (order) information for specific visual cues as well as for specific motor responses. The second aim is to determine whether the medial prefrontal cortex in the rat mediates memory for frequency. The third aim is to determine whether the medial prefrontal cortex is involved with retrospective and prospective coding of sequential information. The fourth aim is to determine possible uniqueness of function of the medial prefrontal cortex by examining the role of the orbito-insular prefrontal cortex, dorsolateral frontal cortex and parietal cortex in mediating temporal information. It is hoped that the information gleaned from these studies will provide an understanding of the frontal lobe syndrome such that a rational therapeutic intervention can be established.