PREVENTION OF INTRACRANIAL ARTERIAL REACTION TO SAH

预防 SAH 的颅内动脉反应

• 批准号: 3398555
• 负责人: JOHN F ALKSNE
• 金额: $ 16.19万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-09-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3398555
• 关键词: cardiovascular disorder prevention; cerebral ischemia /hypoxia; dosage; drug metabolism; electron microscopy; fibrinolytic agents; histopathology; microscopy; plasmin; subarachnoid hemorrhage; subarachnoid space; vasospasm

This is a proposal to continue work already underway on the prevention of the intracranial arterial necrosis associated with subarachnoid hemorrhage. Previous work has demonstrated that this vasculopathy can be markedly reduced by the injection of the thromboletic agent Plasmin directly into the cisterna magna. This proposal is to further characterize the proper timing to insure maximal protection and to determine if prevention of the vasculopathy will also prevent delayed vasospasm.

这是一项建议，继续开展已经在进行的预防 蛛网膜下腔相关性颅内动脉坏死 出血 以前的工作已经证明，这种血管病变可以是 通过注射血栓形成剂纤溶酶显著降低 直接进入小脑延髓池 这一建议是为了进一步说明 适当的时机，以确保最大的保护，并确定是否 预防血管病变还可以预防迟发性血管痉挛。

项目成果

Effect of uridine 5'-diphosphate on cryogenic brain edema in rabbits.

尿苷5-二磷酸对家兔低温脑水肿的影响。

• DOI: 10.1161/01.str.20.12.1694
• 发表时间: 1989
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Yoshida,S;Alksne,JF;Seelig,JM;Bailey,MD;Moore,SS;Kitamura,K
• 通讯作者: Kitamura,K