PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
批准号:
3399863
负责人:
DAVID P RICHMAN
金额:
$10.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-07-01 至 1987-06-30
中文摘要
这一建议的目的是利用我们最近的两项观察
英文摘要
This proposal is designed to use two recent observations made in our
laboratory to determine the mechanisms by which antibodies to acetylcholine
receptor (AChR) induce myasthenia gravis (MG). The observations, which run
somewhat counter to current theories, are: l) monoclonal antibodies
(mcabs) that block the function of intact AChR induce severe acute
myasthenia in the absence of histological abnormalities; 2) chronic
administration in rats of anti-AChR mcabs incapable of blocking AChR
function results in the histological abnormalities of MG in the absence of
clinical or electromyographic abnormality. We propose to determine the
precise nature of the chronic syndrome to establish whether the
histological abnormality has pathogenic significance or whether it
represents the healed stage of a more severe endplate injury similar to the
acute phase of experimental myasthenia (EAMG). We also propose to
determine whether the addition of either mcabs that block AChR function,
mcabs more efficient in inducing increased AChR turnover, or combinations
of many mcabs are required to produce the complete MG picture of
histological, clinical, and electrophysiological abnormalities. We will
make use of purified anti-AChR mcabs and Ig fragments and will study
clinical weakness, electromyographic function, miniature endplate potential
amplitudes, muscle content of AChR and AChR-mcab complexes, light and
electron microscopic changes, and a number of serological and immune
parameters. The combination of immunological, biochemical,
electrophysiological, and pathological techniques should provide
information on the sequence of events that leads to MG. This information
may well suggest new means of treating or preventing this disease. In
addition, since our present knowledge of MG makes it a "model" autoimmune
disease, the information gained in this study will likely be applicable to
other less well-understood autoimmune diseases.
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会议论文
Development of Animal Models of Anti-MuSK Myasthenia
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批准号:8048710
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项目类别:
-
资助金额:$22.96万
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财政年份:2010
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负责人:DAVID P RICHMAN
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依托单位:
Development of Animal Models of Anti-MuSK Myasthenia
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批准号:8152160
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项目类别:
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资助金额:$18.81万
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财政年份:2010
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负责人:DAVID P RICHMAN
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依托单位:
IX INTERNATIONAL CONFERENCE ON MYASTHENIA GRAVIS
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批准号:2038867
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项目类别:
-
资助金额:$2.0万
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财政年份:1997
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负责人:DAVID P RICHMAN
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依托单位:
STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
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批准号:3100129
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项目类别:
-
资助金额:$65.68万
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财政年份:1987
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负责人:DAVID P RICHMAN
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依托单位:
STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
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批准号:3100128
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项目类别:
-
资助金额:$18.06万
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财政年份:1987
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负责人:DAVID P RICHMAN
-
依托单位:
STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
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批准号:3100131
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项目类别:
-
资助金额:$58.46万
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财政年份:1987
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负责人:DAVID P RICHMAN
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依托单位:
STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
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批准号:3100126
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项目类别:
-
资助金额:$72.85万
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财政年份:1987
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负责人:DAVID P RICHMAN
-
依托单位:
STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
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批准号:3100130
-
项目类别:
-
资助金额:$61.12万
-
财政年份:1987
-
负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399864
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项目类别:
-
资助金额:$10.72万
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财政年份:1984
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负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399867
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项目类别:
-
资助金额:$16.08万
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财政年份:1984
-
负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399865
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项目类别:
-
资助金额:$11.25万
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财政年份:1984
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负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA
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批准号:2263670
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项目类别:
-
资助金额:$22.19万
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财政年份:1984
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负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399859
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项目类别:
-
资助金额:$12.17万
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财政年份:1984
-
负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399860
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项目类别:
-
资助金额:$19.04万
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财政年份:1984
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负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA
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批准号:2263669
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项目类别:
-
资助金额:$21.16万
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财政年份:1984
-
负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA
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批准号:2263668
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项目类别:
-
资助金额:$17.16万
-
财政年份:1984
-
负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399862
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项目类别:
-
资助金额:$10.75万
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财政年份:1984
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负责人:DAVID P RICHMAN
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依托单位:
PATHOGENIC MECHANISMS IN MYASTHENIA GRAVIS
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批准号:3399866
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项目类别:
-
资助金额:$16.73万
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财政年份:1984
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负责人:DAVID P RICHMAN
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依托单位:
ANTIIDIOTYPIC ANTIBODIES IN MYASTHENIA
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批准号:2262830
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项目类别:
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资助金额:$22.26万
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财政年份:1979
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负责人:DAVID P RICHMAN
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依托单位:
ANTI-IDIOTYPIC ANTIBODIES IN MYASTHENIA
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批准号:3396281
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项目类别:
-
资助金额:$17.15万
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财政年份:1979
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负责人:DAVID P RICHMAN
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依托单位: