EXPERIMENTAL TENSOR MODELING OF HEAD SENSORIMOTOR SYSTEM

大量的初步研究，现在也获得了实验结果 由国外独立科学家证明，中枢神经系统的张量模型 十多年来由PI开发的函数可以定量地预测 神经网络实现感觉-运动转换。这些可测试的 预测是基于前庭的几何排列。 传感器和肌肉效应器。为了对理论进行实验测试 在几何图形已知的位置选择系统。没有任何限制 关于此几何图形的复杂性，因为要构建的模型可以 处理坐标系可能为非正交性的系统，并且 肌肉的数量可能远远超过自由度的数量。这个 选择是一般的、非正交的、过完备的系统 前庭结肠反射(VCR)是一种闭环式感觉运动系统， 产生颈部肌肉运动信号，定位头部，由 前庭感觉信号直接来自头部的运动。这个 类似的视网膜反射(RCR)将与VCR进行比较。 协管会过去和未来的贡献对 VCR和RCR在肌肉中功能的实验定义 对身体旋转的反应以及神经元信号所揭示的 涉及到的路径。为研究患者的反应而制定的程序 多分量前庭和颈部肌肉装置对三个旋转的影响 维度，将作为测试对 VCR的张量模型。这种实验和测试的融合 理论方法提供了难得的合作机会 VCR和RCR的研究。申请的资金将用于进一步 VCR和RCR张量模型的构建和检验，基于 半规管和颈部肌肉几何形态的定量测量 并将张量模型与实验数据联系起来。模型将是 设计、构建、测试并应用于特定的进一步实验 范例，如小脑切除术。实验测试包括比较 空间属性的度量，例如对 VCR和RCR信号的旋转方向。它们将从 颈部肌肉和脑干神经元，以及与预测 该模型包括完整的和切除小脑的准备。田纳西州 建模似乎已经通过了这些测试，因此预计将 变得适用于了解其他感觉运动中枢神经系统 功能，最终促进受损感觉运动的康复 功能。

Substantial preliminary studies, and now also experimental results obtained by independent scientists abroad, demonstrate that the tensor model of CNS function, developed by the PI over a decade can quantitatively predict how neuronal networks implement sensorimotor transformations. These testable predictions are based upon the geometrical arrangement of the vestibular sensors and muscle effectors. For the experimental testing of the theory a system is selected where the geometry is known. There are no restrictions on the complexity of this geometry, since the model to be constructed can deal with systems where the coordinate frame may be non-orthoganal and the number of muscles may well exceed the number of degrees of freedom. The choice is the general, non-orthogonal, overcomplete system of the vestibulocollic reflex (VCR) a closed-loop sensorimotor system that generates neck-muscle motor signals that position the head, controlled by vestibular sensory signals arising directly from head movements. The analogous retinocollic reflex (RCR) will be compared to the VCR. The Co-PI's contribution in the past and the future is instrumental to the experimental definition of the function of the VCR & RCR, both in muscular response to body rotations and as revealed by the signals in neuronal pathways involved. The procedures developed for studying responses of the multicomponent vestibular and neck-muscle apparatus to rotations in three dimensions, will serve as ideal means for testing predictions of a tensorial model of the VCR. This convergence of experimental and theoretical approaches provides a rare opportunity for a collaborative study of VCR & RCR. Funds requested will be directed towards further constructing and testing a tensorial model of VCR & RCR, based on quantitative measurements of semicircular canal and neck muscle geometry and to relating the tensor model to experimental data. The model will be designed, constructed, tested, and applied to specific further experimental paradigms, such as cerebellectomy. Experimental tests include comparing measurements of spatial properties, such as dependency on rotational-directions, of VCR & RCR signals. They will be recorded from neck muscles and brainstem neurons, and results related to predictions of the model both for intact and cerebellectomized preparation. Tensorial modeling already appears to be passing these tests and thus is expected to become applicable to gaining understanding of other sensorimotor CNS functions, eventually facilitating rehabilitation of impaired sensorimotor function.