Tools for manipulating neuronal activity for behavioural studies

用于行为研究的操纵神经元活动的工具

• 批准号: FT160100056
• 负责人: Dr John Yu-luen Lin
• 金额: $ 47.49万
• 依托单位: University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT160100056
• 关键词: Tools; manipulating; neuronal; activity; behavioural

This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This project is expected to increase understanding of brain function at the cellular and system levels, and advance Australia’s multidisciplinary research capacity in neuroscience, cognitive sciences and nanobiotechnology to ultimately treat neurological disorders.

该项目旨在开发光遗传学工具，神经科学家可以用它来更好地了解大脑回路和特定神经元对行为的功能影响。将大脑中单个神经元的活动与特定行为联系起来是神经科学的一个重大挑战。光遗传学通过使用光来控制神经元的活动来实现这一点。这是对行为和神经回路的先进理解。该项目有望在细胞和系统水平上增加对大脑功能的理解，并推进澳大利亚在神经科学、认知科学和纳米生物技术方面的多学科研究能力，最终治疗神经系统疾病。